Abstract
A small population of human T-cell leukemia virus Type I (HTLV-I) carriers develop adult T-cell leukemia after a long incubation period. The results of a series of experiments using animal models suggest that insufficiency of HTLV-I-specific T-cell response induced by vertical HTLV-I infection allows enlargement of the HTLV-I-infected cell reservoir in vivo, a crucial risk factor of adult T-cell leukemia. In this review it is proposed that prophylactic Tax-targeted vaccines for the high-risk group of adult T-cell leukemia, which is characterized by low HTLV-I-specific T-cell response and high proviral load, can reduce the risk. Immunological studies on adult T-cell leukemia patients after hematopoietic stem cell transplantation also suggest that Tax-targeted immunotherapy may be effective against full-blown disease, although its indication may be limited.
| Original language | English |
|---|---|
| Pages (from-to) | 369-376 |
| Number of pages | 8 |
| Journal | Expert Review of Anticancer Therapy |
| Volume | 4 |
| Issue number | 3 |
| Publication status | Published - 2004 Jun |
| Externally published | Yes |
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Keywords
- Adult T-cell leukemia
- Hematopoietic stem cell transplantation
- Human T-cell leukemia virus Type I
- T-cell response
- Tax
ASJC Scopus subject areas
- Cancer Research
- Pharmacology
Cite this
Adult T-cell leukemia : Future prophylaxis and immunotherapy. / Kannagi, Mari; Harashima, Nanae; Kurihara, Kiyoshi; Utsunomiya, Atae; Tanosaki, Ryuji; Masuda, Masato.
In: Expert Review of Anticancer Therapy, Vol. 4, No. 3, 06.2004, p. 369-376.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Adult T-cell leukemia
T2 - Future prophylaxis and immunotherapy
AU - Kannagi, Mari
AU - Harashima, Nanae
AU - Kurihara, Kiyoshi
AU - Utsunomiya, Atae
AU - Tanosaki, Ryuji
AU - Masuda, Masato
PY - 2004/6
Y1 - 2004/6
N2 - A small population of human T-cell leukemia virus Type I (HTLV-I) carriers develop adult T-cell leukemia after a long incubation period. The results of a series of experiments using animal models suggest that insufficiency of HTLV-I-specific T-cell response induced by vertical HTLV-I infection allows enlargement of the HTLV-I-infected cell reservoir in vivo, a crucial risk factor of adult T-cell leukemia. In this review it is proposed that prophylactic Tax-targeted vaccines for the high-risk group of adult T-cell leukemia, which is characterized by low HTLV-I-specific T-cell response and high proviral load, can reduce the risk. Immunological studies on adult T-cell leukemia patients after hematopoietic stem cell transplantation also suggest that Tax-targeted immunotherapy may be effective against full-blown disease, although its indication may be limited.
AB - A small population of human T-cell leukemia virus Type I (HTLV-I) carriers develop adult T-cell leukemia after a long incubation period. The results of a series of experiments using animal models suggest that insufficiency of HTLV-I-specific T-cell response induced by vertical HTLV-I infection allows enlargement of the HTLV-I-infected cell reservoir in vivo, a crucial risk factor of adult T-cell leukemia. In this review it is proposed that prophylactic Tax-targeted vaccines for the high-risk group of adult T-cell leukemia, which is characterized by low HTLV-I-specific T-cell response and high proviral load, can reduce the risk. Immunological studies on adult T-cell leukemia patients after hematopoietic stem cell transplantation also suggest that Tax-targeted immunotherapy may be effective against full-blown disease, although its indication may be limited.
KW - Adult T-cell leukemia
KW - Hematopoietic stem cell transplantation
KW - Human T-cell leukemia virus Type I
KW - T-cell response
KW - Tax
UR - http://www.scopus.com/inward/record.url?scp=2942542883&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2942542883&partnerID=8YFLogxK
M3 - Review article
C2 - 15161436
AN - SCOPUS:2942542883
VL - 4
SP - 369
EP - 376
JO - Expert Review of Anticancer Therapy
JF - Expert Review of Anticancer Therapy
SN - 1473-7140
IS - 3
ER -