TY - JOUR
T1 - Advances in capillary electrophoresis mass spectrometry for metabolomics
AU - Soga, Tomoyoshi
N1 - Funding Information:
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Tomoyoshi Soga reports financial support was provided by Keio University Institute for Advanced Biosciences.This work was supported by AMED, Japan, Grant Number JP21zf0127001; JST, Japan, CREST Grant Number JPMJCR2123 and research funds from the Yamagata prefectural government and the city of Tsuruoka.
Funding Information:
This work was supported by AMED, Japan, Grant Number JP21zf0127001 ; JST , Japan, CREST Grant Number JPMJCR2123 and research funds from the Yamagata prefectural government and the city of Tsuruoka.
Publisher Copyright:
© 2022 The Author
PY - 2023/1
Y1 - 2023/1
N2 - Capillary electrophoresis mass spectrometry (CE-MS) is now regarded as a powerful tool for the comprehensive analysis of low-molecular-weight charged metabolites. Over the past decades, several CE-MS methods have been established and made significant contributions to metabolomics research in various areas. This review describes the general strategies and principles of the CE-MS-based metabolomics analyses, including sample preparation, CE separation modes, interfacing techniques, and mass spectrometers. Furthermore, new techniques to increase throughput ability in CE-MS for metabolomics are highlighted. Finally, general conclusions and perspectives are provided.
AB - Capillary electrophoresis mass spectrometry (CE-MS) is now regarded as a powerful tool for the comprehensive analysis of low-molecular-weight charged metabolites. Over the past decades, several CE-MS methods have been established and made significant contributions to metabolomics research in various areas. This review describes the general strategies and principles of the CE-MS-based metabolomics analyses, including sample preparation, CE separation modes, interfacing techniques, and mass spectrometers. Furthermore, new techniques to increase throughput ability in CE-MS for metabolomics are highlighted. Finally, general conclusions and perspectives are provided.
KW - Capillary electrophoresis
KW - Mass spectrometry
KW - Metabolome
KW - Metabolomics
KW - Multisegment injection
KW - Sheath-flow
KW - Sheathless
UR - http://www.scopus.com/inward/record.url?scp=85144030689&partnerID=8YFLogxK
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U2 - 10.1016/j.trac.2022.116883
DO - 10.1016/j.trac.2022.116883
M3 - Review article
AN - SCOPUS:85144030689
SN - 0165-9936
VL - 158
JO - TrAC - Trends in Analytical Chemistry
JF - TrAC - Trends in Analytical Chemistry
M1 - 116883
ER -