[Adverse events of psychotropic drugs].

Koichiro Watanabe, Toshiaki Kikuchi

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The authors discuss adverse events which are often missed but clinicians should pay attention to in order to preserve patients'quality of life(QOL). Among mood stabilizers, lithium may cause a urinary volume increase, hyperparathyroidism, and serum calcium elevation; sodium valproate possibly increases androgenic hormone levels and the risk of polycystic ovary syndrome (PCOS) as well as hypothyroidism. Moreover, in addition to teratogenesis, it has been reported that fetal exposure to a higher dose of valproate is associated with a lower intelligence quotient and higher incidence of autism spectrum disorders in children. Antidepressants with a higher affinity for serotonin transporters might induce gastrointestinal bleeding, and some antidepressants cause sexual dysfunction more frequently than others. Activation syndrome is still a key side effect which should be noted. Regarding the adverse events of antipsychotics, subjective side effects unpleasant to patients such as dysphoria and a lower subjective well-being should not be overlooked. We clinicians have to cope with adverse events worsening the QOL of patients with psychiatric disorders and, therefore, we need to adopt appropriate counter-measures.

Original languageEnglish
Pages (from-to)323-331
Number of pages9
JournalSeishin shinkeigaku zasshi = Psychiatria et neurologia Japonica
Volume116
Issue number4
Publication statusPublished - 2014 Jan 1
Externally publishedYes

Fingerprint

Psychotropic Drugs
Valproic Acid
Antidepressive Agents
Quality of Life
Teratogenesis
Serotonin Plasma Membrane Transport Proteins
Hyperparathyroidism
Polycystic Ovary Syndrome
Hypothyroidism
Intelligence
Lithium
Antipsychotic Agents
Psychiatry
Hormones
Hemorrhage
Calcium
Incidence
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

[Adverse events of psychotropic drugs]. / Watanabe, Koichiro; Kikuchi, Toshiaki.

In: Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, Vol. 116, No. 4, 01.01.2014, p. 323-331.

Research output: Contribution to journalReview article

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