AFP-producing squamous cell carcinoma of the lung in an adolescent

Hisao Asamura; Haruhiko Nakayama; Haruniko Kondo; Ryosuke Tsuchiya; Ryosuke Ono; Masayuki Noguchi; Hiroshi Yoda; Tsuguo Naruke

doi:10.1093/oxfordjournals.jjco.a023181

AFP-producing squamous cell carcinoma of the lung in an adolescent

Hisao Asamura, Haruhiko Nakayama, Haruniko Kondo, Ryosuke Tsuchiya, Ryosuke Ono, Masayuki Noguchi, Hiroshi Yoda, Tsuguo Naruke

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

We report a case of primary lung cancer in a 16-year-old boy. A histologic diagnosis of squamous cell carcinoma was made by bronchoscopic biopsy before surgery. The serum alpha-fetoprotein (AFP) level was markedly elevated at 193 ng/dl. Preoperative and postoperative evaluation revealed no evidence of scrotal mass. We performed right pneumonectomy with combined resection of the invaded portion of the left atrium under extracorporeal circulation. Despite the rapid improvement in the patient's general condition after surgery, the AFP level continued to increase without a transient decrease and reached 3160 ng/ml on the 23rd postoperative day. When the patient was readmitted because of dyspnea and headache on the 36th postoperative day, hypercalcemia of 13.9 mg/dl was noted, and this was resistant to subsequent treatment. The patient died on the 46th postoperative day.

Original language	English
Pages (from-to)	103-106
Number of pages	4
Journal	Japanese journal of clinical oncology
Volume	26
Issue number	2
DOIs	https://doi.org/10.1093/oxfordjournals.jjco.a023181
Publication status	Published - 1996 Apr
Externally published	Yes

Keywords

Adolescent
Alpha-fetoprotein
Lung cancer
Surgery

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/oxfordjournals.jjco.a023181

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title = "AFP-producing squamous cell carcinoma of the lung in an adolescent",

abstract = "We report a case of primary lung cancer in a 16-year-old boy. A histologic diagnosis of squamous cell carcinoma was made by bronchoscopic biopsy before surgery. The serum alpha-fetoprotein (AFP) level was markedly elevated at 193 ng/dl. Preoperative and postoperative evaluation revealed no evidence of scrotal mass. We performed right pneumonectomy with combined resection of the invaded portion of the left atrium under extracorporeal circulation. Despite the rapid improvement in the patient's general condition after surgery, the AFP level continued to increase without a transient decrease and reached 3160 ng/ml on the 23rd postoperative day. When the patient was readmitted because of dyspnea and headache on the 36th postoperative day, hypercalcemia of 13.9 mg/dl was noted, and this was resistant to subsequent treatment. The patient died on the 46th postoperative day.",

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author = "Hisao Asamura and Haruhiko Nakayama and Haruniko Kondo and Ryosuke Tsuchiya and Ryosuke Ono and Masayuki Noguchi and Hiroshi Yoda and Tsuguo Naruke",

year = "1996",

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doi = "10.1093/oxfordjournals.jjco.a023181",

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T1 - AFP-producing squamous cell carcinoma of the lung in an adolescent

AU - Asamura, Hisao

AU - Nakayama, Haruhiko

AU - Kondo, Haruniko

AU - Tsuchiya, Ryosuke

AU - Ono, Ryosuke

AU - Noguchi, Masayuki

AU - Yoda, Hiroshi

AU - Naruke, Tsuguo

PY - 1996/4

Y1 - 1996/4

N2 - We report a case of primary lung cancer in a 16-year-old boy. A histologic diagnosis of squamous cell carcinoma was made by bronchoscopic biopsy before surgery. The serum alpha-fetoprotein (AFP) level was markedly elevated at 193 ng/dl. Preoperative and postoperative evaluation revealed no evidence of scrotal mass. We performed right pneumonectomy with combined resection of the invaded portion of the left atrium under extracorporeal circulation. Despite the rapid improvement in the patient's general condition after surgery, the AFP level continued to increase without a transient decrease and reached 3160 ng/ml on the 23rd postoperative day. When the patient was readmitted because of dyspnea and headache on the 36th postoperative day, hypercalcemia of 13.9 mg/dl was noted, and this was resistant to subsequent treatment. The patient died on the 46th postoperative day.

AB - We report a case of primary lung cancer in a 16-year-old boy. A histologic diagnosis of squamous cell carcinoma was made by bronchoscopic biopsy before surgery. The serum alpha-fetoprotein (AFP) level was markedly elevated at 193 ng/dl. Preoperative and postoperative evaluation revealed no evidence of scrotal mass. We performed right pneumonectomy with combined resection of the invaded portion of the left atrium under extracorporeal circulation. Despite the rapid improvement in the patient's general condition after surgery, the AFP level continued to increase without a transient decrease and reached 3160 ng/ml on the 23rd postoperative day. When the patient was readmitted because of dyspnea and headache on the 36th postoperative day, hypercalcemia of 13.9 mg/dl was noted, and this was resistant to subsequent treatment. The patient died on the 46th postoperative day.

KW - Adolescent

KW - Alpha-fetoprotein

KW - Lung cancer

KW - Surgery

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AFP-producing squamous cell carcinoma of the lung in an adolescent

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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