AFP-producing squamous cell carcinoma of the lung in an adolescent

Hisao Asamura, Haruhiko Nakayama, Haruniko Kondo, Ryosuke Tsuchiya, Ryosuke Ono, Masayuki Noguchi, Hiroshi Yoda, Tsuguo Naruke

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


We report a case of primary lung cancer in a 16-year-old boy. A histologic diagnosis of squamous cell carcinoma was made by bronchoscopic biopsy before surgery. The serum alpha-fetoprotein (AFP) level was markedly elevated at 193 ng/dl. Preoperative and postoperative evaluation revealed no evidence of scrotal mass. We performed right pneumonectomy with combined resection of the invaded portion of the left atrium under extracorporeal circulation. Despite the rapid improvement in the patient's general condition after surgery, the AFP level continued to increase without a transient decrease and reached 3160 ng/ml on the 23rd postoperative day. When the patient was readmitted because of dyspnea and headache on the 36th postoperative day, hypercalcemia of 13.9 mg/dl was noted, and this was resistant to subsequent treatment. The patient died on the 46th postoperative day.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalJapanese journal of clinical oncology
Issue number2
Publication statusPublished - 1996 Apr
Externally publishedYes


  • Adolescent
  • Alpha-fetoprotein
  • Lung cancer
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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