Agaricus brasiliensis KA21 May Prevent Diet-Induced Nash through Its Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Activities in the Liver

Anna Nakamura, Qi Zhu, Yoko Yokoyama, Naho Kitamura, Sena Uchida, Kayo Kumadaki, Kazuo Tsubota, Mitsuhiro Watanabe

Research output: Contribution to journalArticle

Abstract

Non-alcoholic steatohepatitis (NASH) is a progressive disease that occurs in the liver. As the number of people with NASH has increased, effective prevention and treatment strategies are needed. Agaricus brasiliensis KA21 (AGA) is a mushroom native to Brazil and is considered a healthy food because of its purported health benefits, including its antioxidant properties. In this study, we focused on the oxidative stress that accompanies the onset of NASH and examined whether AGA can prevent NASH development through its antioxidant activity. We used a mouse model of NASH in which pathogenesis was promoted by dietary induction. Supplementation with AGA attenuated the development of hepatic fibrosis, which is a characteristic feature of late-stage NASH. This effect appeared to be mechanistically linked to an AGA-promoted reduction in hepatic oxidative stress. These results demonstrate a novel role for AGA in NASH prevention.

Original languageEnglish
Article number546
JournalFoods
Volume8
Issue number11
DOIs
Publication statusPublished - 2019 Jan 1

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Agaricus subrufescens
Agaricus
Fatty Liver
alcoholism
Anti-Inflammatory Agents
oxidative stress
Antioxidants
Diet
antioxidants
liver
liver cirrhosis
Liver
liver diseases
diet
mushrooms
pathogenesis
antioxidant activity
animal models
Brazil
Oxidative Stress

Keywords

  • Agaricus brasiliensis KA21
  • Anti-inflammation
  • Anti-oxidant
  • Non-alcoholic fatty liver disease
  • Non-alcoholic steatohepatitis

ASJC Scopus subject areas

  • Food Science
  • Microbiology
  • Health(social science)
  • Health Professions (miscellaneous)
  • Plant Science

Cite this

Agaricus brasiliensis KA21 May Prevent Diet-Induced Nash through Its Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Activities in the Liver. / Nakamura, Anna; Zhu, Qi; Yokoyama, Yoko; Kitamura, Naho; Uchida, Sena; Kumadaki, Kayo; Tsubota, Kazuo; Watanabe, Mitsuhiro.

In: Foods, Vol. 8, No. 11, 546, 01.01.2019.

Research output: Contribution to journalArticle

Nakamura, Anna ; Zhu, Qi ; Yokoyama, Yoko ; Kitamura, Naho ; Uchida, Sena ; Kumadaki, Kayo ; Tsubota, Kazuo ; Watanabe, Mitsuhiro. / Agaricus brasiliensis KA21 May Prevent Diet-Induced Nash through Its Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Activities in the Liver. In: Foods. 2019 ; Vol. 8, No. 11.
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