Age-dependent chemosensitive pontine inhibition of medullary respiratory rhythm generation in the isolated brainstem of the neonatal rat

Yoko Ito, Yoshitaka Oyamada, Kazuhiro Yamaguchi

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Age-dependence and chemosensitivity of the pontine inhibitory effect on medullary respiratory rhythm generation were examined in the isolated brainstem-spinal cord of the neonatal rat. In early preparations (days 1-2), the increase in RR (ΔRR) induced by the pons resection was larger in 8% CO2 (pH 7.2) than in 2% CO2 (pH 7.8). That difference was not found in late preparations (days 3-4). Under a given pH, the ΔRR was larger in early preparations than in late preparations.

Original languageEnglish
Pages (from-to)418-420
Number of pages3
JournalBrain Research
Issue number2
Publication statusPublished - 2000 Dec 29



  • A5 neurones
  • Chemosensitivity
  • Locus coeruleus
  • Medulla
  • Pons
  • Respiration

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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