Age-related changes in cortical bone in men: Metacarpal bone mass measurement study

Jun Iwamoto, Tsuyoshi Takeda, Shoichi Ichimura, Yasunori Tsukimura, Yoshiaki Toyama

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Metacarpal cortical bone mass was measured in 507 healthy Japanese men aged 40-95 years, using a microdensitometer to determine age-related changes in cortical bone in these middle-aged and elderly men. Total bone mass showed a significant negative correlation with age (r = -0.281; P < 0.0001). While bone width showed no significant correlation with age, bone marrow width showed a significant positive correlation (r = 0.210; P < 0.0001), and cortical bone width and cortical bone density showed a significant negative correlation with age (r = -0.265; P < 0.0001; r = -0.268; P < 0.0001, respectively). On the other hand, cortical bone width and cortical bone density showed a significant positive correlation with total bone mass (r = 0.814; P < 0.0001; r = 0.474, P < 0.0001, respectively). These findings suggest that cortical bone mass decreases significantly with aging in middle- aged and elderly men, perhaps as a result of two factors decreased cortical bone width, ie, cortical bone thinning due to bone loss at the endosteal side of the cortex, and decreased cortical bone density due to progression of intracortical porosity. Cortical bone thinning may influence age-related cortical bone loss more than decreasing cortical bone density.

Original languageEnglish
Pages (from-to)4-9
Number of pages6
JournalJournal of Orthopaedic Science
Volume5
Issue number1
Publication statusPublished - 2000

Fingerprint

Metacarpal Bones
Bone and Bones
Bone Density
Cortical Bone
Hand Bones
Porosity
Osteoporosis

Keywords

  • Aging
  • Cortical bone
  • Men

ASJC Scopus subject areas

  • Surgery

Cite this

Iwamoto, J., Takeda, T., Ichimura, S., Tsukimura, Y., & Toyama, Y. (2000). Age-related changes in cortical bone in men: Metacarpal bone mass measurement study. Journal of Orthopaedic Science, 5(1), 4-9.

Age-related changes in cortical bone in men : Metacarpal bone mass measurement study. / Iwamoto, Jun; Takeda, Tsuyoshi; Ichimura, Shoichi; Tsukimura, Yasunori; Toyama, Yoshiaki.

In: Journal of Orthopaedic Science, Vol. 5, No. 1, 2000, p. 4-9.

Research output: Contribution to journalArticle

Iwamoto, J, Takeda, T, Ichimura, S, Tsukimura, Y & Toyama, Y 2000, 'Age-related changes in cortical bone in men: Metacarpal bone mass measurement study', Journal of Orthopaedic Science, vol. 5, no. 1, pp. 4-9.
Iwamoto, Jun ; Takeda, Tsuyoshi ; Ichimura, Shoichi ; Tsukimura, Yasunori ; Toyama, Yoshiaki. / Age-related changes in cortical bone in men : Metacarpal bone mass measurement study. In: Journal of Orthopaedic Science. 2000 ; Vol. 5, No. 1. pp. 4-9.
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