Aging of the hematopoietic stem cells niche

Ayako Nakamura-Ishizu, Toshio Suda

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Homeostasis of the hematopoietic system has its roots in the maintenance of hematopoietic stem cells (HSCs) in the bone marrow (BM). HSCs change both phenotypically and functionally with physiological age. The alterations noted in aged HSCs are thought to be a consequence of both cell-intrinsic and extrinsic changes. We review here the age-related changes that the BM microenvironment exerts on HSCs.

Original languageEnglish
Pages (from-to)317-325
Number of pages9
JournalInternational journal of hematology
Volume100
Issue number4
DOIs
Publication statusPublished - 2014 Oct 9

Keywords

  • Aging
  • Bone marrow
  • Hematopoietic stem cells
  • Niche

ASJC Scopus subject areas

  • Hematology

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