Albuminuria is an independent predictor of all-cause and cardiovascular mortality in the Japanese population: The Takahata study

Tsuneo Konta, Kosuke Kudo, Hiroko Sato, Kazunobu Ichikawa, Ami Ikeda, Kazuko Suzuki, Atsushi Hirayama, Yoko Shibata, Tetsu Watanabe, Makoto Daimon, Takeo Kato, Yoshiyuki Ueno, Takamasa Kayama, Isao Kubota

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: Albuminuria is a known risk factor for cardiovascular events and premature deaths. However, the association between urinary albumin excretion and mortality is unknown in the Japanese population. To clarify this, we conducted a community-based longitudinal study. Methods: This study included 3,445 registered Japanese subjects (mean age 62.6 years), with a 7-year follow-up. Albuminuria was defined as a urine albumin-creatinine ratio (ACR) ≥30 mg/g in the morning spot urine. Results: Subjects with albuminuria (n = 514, 14.9 %) were older and showed a higher prevalence of hypertension, obesity, and diabetes and lower values of estimated glomerular filtration rate (eGFR) than those without albuminuria (n = 2931, 85.1 %). During the follow-up, 138 subjects died. A Kaplan-Meier analysis showed that all-cause mortality significantly increased along with the increase in urine albumin excretion (log-rank test, P < 0.001). The subjects with albuminuria showed a significantly higher mortality rate than those without albuminuria (7.4 vs. 3.4 %; log-rank test, P < 0.001). A Cox proportional hazard model analysis after adjusting for possible confounders showed that albuminuria was an independent risk factor for all-cause and cardiovascular mortality (hazard ratio [HR] 1.69, 95 % confidence interval [CI] 1.12-2.56 and HR 2.27, 95 % CI 1.10-4.70, respectively) but not for noncardiovascular mortality. These associations were preserved after excluding subjects with high ACR (≥300 mg/g). Conclusions: Albuminuria was a risk factor for all-cause and cardiovascular mortality in the Japanese population. To detect subjects with a high risk for premature death, measuring urinary albumin excretion might be useful.

Original languageEnglish
Pages (from-to)805-810
Number of pages6
JournalClinical and experimental nephrology
Volume17
Issue number6
DOIs
Publication statusPublished - 2013 Dec 1

Keywords

  • Albuminuria
  • Cohort
  • Mortality
  • Population

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Albuminuria is an independent predictor of all-cause and cardiovascular mortality in the Japanese population: The Takahata study'. Together they form a unique fingerprint.

  • Cite this

    Konta, T., Kudo, K., Sato, H., Ichikawa, K., Ikeda, A., Suzuki, K., Hirayama, A., Shibata, Y., Watanabe, T., Daimon, M., Kato, T., Ueno, Y., Kayama, T., & Kubota, I. (2013). Albuminuria is an independent predictor of all-cause and cardiovascular mortality in the Japanese population: The Takahata study. Clinical and experimental nephrology, 17(6), 805-810. https://doi.org/10.1007/s10157-013-0770-3