Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer

Akira Yokoyama, Chikatoshi Katada, Tetsuji Yokoyama, Tomonori Yano, Kazuhiro Kaneko, Ichiro Oda, Yuichi Shimizu, Hisashi Doyama, Tomoyuki Koike, Kohei Takizawa, Motohiro Hirao, Hiroyuki Okada, Takako Yoshii, Kazuo Konishi, Takenori Yamanouchi, Takashi Tsuda, Tai Omori, Nozomu Kobayashi, Haruhisa Suzuki, Satoshi Tanabe & 5 others Keisuke Hori, Norisuke Nakayama, Hirofumi Kawakubo, Hideki Ishikawa, Manabu Muto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background Alcohol consumption combined with inactive aldehyde dehydrogenase-2 (ALDH2) and the presence of multiple esophageal Lugol-voiding lesions (LVLs; dysplasia) are strong predictors for multiple development of esophageal squamous cell carcinoma (ESCC) in East Asians. We invented a health risk appraisal (HRA) model for predicting the risk of ESCC based on drinking, smoking, dietary habits, and alcohol flushing, i.e., past or present facial flushing after drinking a glass of beer, a surrogate marker for inactive ALDH2. Methods Prospective follow-up examinations (median follow-up time, 50.3 months) were performed in 278 Japanese men after endoscopic mucosectomy for early ESCC (UMIN Clinical Trials Registry ID: UMIN000001676).Results Sixty-four subjects developed metachronous ESCC. A receiver operating characteristic curve showed that HRA scores ô12 best predicted the development of metachronous ESCC. The ESCC detection rate per 100 person-years was 9.8 in the high-HRA-score group (n = 104) and 4.5 in the low-HRA-score group (n = 174), and the risk of development of metachronous ESCC was higher in the high-HRA-score group than in the low-HRA-score group (adjusted hazard ratio: 2.00 [95% CI: 1.12-3.30]). Multiple LVLs was a very strong predictor of the development of metachronous SCC, but high HRA scores predicted it independently. The cumulative incidences of metachronous ESCC decreased after drinking cessation in the high-HRA-score drinker group (adjusted hazard ratio: 0.37 [0.14-0.97]). Conclusions Both the HRA model that included alcohol flushing and the multiple LVL grade predicted the development of metachronous ESCC in Japanese men after endoscopic mucosectomy for ESCC. Drinking cessation in the high-HRA-score drinker group reduced the rate of metachronous ESCC.

Original languageEnglish
Article numbere0175182
JournalPLoS One
Volume12
Issue number4
DOIs
Publication statusPublished - 2017 Apr 1

Fingerprint

Alcohol Abstinence
esophageal neoplasms
Health Status Indicators
Second Primary Neoplasms
Esophageal Neoplasms
Health risks
squamous cell carcinoma
Risk assessment
risk assessment
alcohols
Alcohols
drinking
Drinking
Aldehyde Dehydrogenase
aldehyde dehydrogenase
Hazards
Esophageal Squamous Cell Carcinoma
Epithelial Cells
Beer
Feeding Behavior

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer. / Yokoyama, Akira; Katada, Chikatoshi; Yokoyama, Tetsuji; Yano, Tomonori; Kaneko, Kazuhiro; Oda, Ichiro; Shimizu, Yuichi; Doyama, Hisashi; Koike, Tomoyuki; Takizawa, Kohei; Hirao, Motohiro; Okada, Hiroyuki; Yoshii, Takako; Konishi, Kazuo; Yamanouchi, Takenori; Tsuda, Takashi; Omori, Tai; Kobayashi, Nozomu; Suzuki, Haruhisa; Tanabe, Satoshi; Hori, Keisuke; Nakayama, Norisuke; Kawakubo, Hirofumi; Ishikawa, Hideki; Muto, Manabu.

In: PLoS One, Vol. 12, No. 4, e0175182, 01.04.2017.

Research output: Contribution to journalArticle

Yokoyama, A, Katada, C, Yokoyama, T, Yano, T, Kaneko, K, Oda, I, Shimizu, Y, Doyama, H, Koike, T, Takizawa, K, Hirao, M, Okada, H, Yoshii, T, Konishi, K, Yamanouchi, T, Tsuda, T, Omori, T, Kobayashi, N, Suzuki, H, Tanabe, S, Hori, K, Nakayama, N, Kawakubo, H, Ishikawa, H & Muto, M 2017, 'Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer', PLoS One, vol. 12, no. 4, e0175182. https://doi.org/10.1371/journal.pone.0175182
Yokoyama, Akira ; Katada, Chikatoshi ; Yokoyama, Tetsuji ; Yano, Tomonori ; Kaneko, Kazuhiro ; Oda, Ichiro ; Shimizu, Yuichi ; Doyama, Hisashi ; Koike, Tomoyuki ; Takizawa, Kohei ; Hirao, Motohiro ; Okada, Hiroyuki ; Yoshii, Takako ; Konishi, Kazuo ; Yamanouchi, Takenori ; Tsuda, Takashi ; Omori, Tai ; Kobayashi, Nozomu ; Suzuki, Haruhisa ; Tanabe, Satoshi ; Hori, Keisuke ; Nakayama, Norisuke ; Kawakubo, Hirofumi ; Ishikawa, Hideki ; Muto, Manabu. / Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer. In: PLoS One. 2017 ; Vol. 12, No. 4.
@article{fc76b05235014e1d88c515ce146caad7,
title = "Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer",
abstract = "Background Alcohol consumption combined with inactive aldehyde dehydrogenase-2 (ALDH2) and the presence of multiple esophageal Lugol-voiding lesions (LVLs; dysplasia) are strong predictors for multiple development of esophageal squamous cell carcinoma (ESCC) in East Asians. We invented a health risk appraisal (HRA) model for predicting the risk of ESCC based on drinking, smoking, dietary habits, and alcohol flushing, i.e., past or present facial flushing after drinking a glass of beer, a surrogate marker for inactive ALDH2. Methods Prospective follow-up examinations (median follow-up time, 50.3 months) were performed in 278 Japanese men after endoscopic mucosectomy for early ESCC (UMIN Clinical Trials Registry ID: UMIN000001676).Results Sixty-four subjects developed metachronous ESCC. A receiver operating characteristic curve showed that HRA scores {\^o}12 best predicted the development of metachronous ESCC. The ESCC detection rate per 100 person-years was 9.8 in the high-HRA-score group (n = 104) and 4.5 in the low-HRA-score group (n = 174), and the risk of development of metachronous ESCC was higher in the high-HRA-score group than in the low-HRA-score group (adjusted hazard ratio: 2.00 [95{\%} CI: 1.12-3.30]). Multiple LVLs was a very strong predictor of the development of metachronous SCC, but high HRA scores predicted it independently. The cumulative incidences of metachronous ESCC decreased after drinking cessation in the high-HRA-score drinker group (adjusted hazard ratio: 0.37 [0.14-0.97]). Conclusions Both the HRA model that included alcohol flushing and the multiple LVL grade predicted the development of metachronous ESCC in Japanese men after endoscopic mucosectomy for ESCC. Drinking cessation in the high-HRA-score drinker group reduced the rate of metachronous ESCC.",
author = "Akira Yokoyama and Chikatoshi Katada and Tetsuji Yokoyama and Tomonori Yano and Kazuhiro Kaneko and Ichiro Oda and Yuichi Shimizu and Hisashi Doyama and Tomoyuki Koike and Kohei Takizawa and Motohiro Hirao and Hiroyuki Okada and Takako Yoshii and Kazuo Konishi and Takenori Yamanouchi and Takashi Tsuda and Tai Omori and Nozomu Kobayashi and Haruhisa Suzuki and Satoshi Tanabe and Keisuke Hori and Norisuke Nakayama and Hirofumi Kawakubo and Hideki Ishikawa and Manabu Muto",
year = "2017",
month = "4",
day = "1",
doi = "10.1371/journal.pone.0175182",
language = "English",
volume = "12",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

TY - JOUR

T1 - Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer

AU - Yokoyama, Akira

AU - Katada, Chikatoshi

AU - Yokoyama, Tetsuji

AU - Yano, Tomonori

AU - Kaneko, Kazuhiro

AU - Oda, Ichiro

AU - Shimizu, Yuichi

AU - Doyama, Hisashi

AU - Koike, Tomoyuki

AU - Takizawa, Kohei

AU - Hirao, Motohiro

AU - Okada, Hiroyuki

AU - Yoshii, Takako

AU - Konishi, Kazuo

AU - Yamanouchi, Takenori

AU - Tsuda, Takashi

AU - Omori, Tai

AU - Kobayashi, Nozomu

AU - Suzuki, Haruhisa

AU - Tanabe, Satoshi

AU - Hori, Keisuke

AU - Nakayama, Norisuke

AU - Kawakubo, Hirofumi

AU - Ishikawa, Hideki

AU - Muto, Manabu

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Background Alcohol consumption combined with inactive aldehyde dehydrogenase-2 (ALDH2) and the presence of multiple esophageal Lugol-voiding lesions (LVLs; dysplasia) are strong predictors for multiple development of esophageal squamous cell carcinoma (ESCC) in East Asians. We invented a health risk appraisal (HRA) model for predicting the risk of ESCC based on drinking, smoking, dietary habits, and alcohol flushing, i.e., past or present facial flushing after drinking a glass of beer, a surrogate marker for inactive ALDH2. Methods Prospective follow-up examinations (median follow-up time, 50.3 months) were performed in 278 Japanese men after endoscopic mucosectomy for early ESCC (UMIN Clinical Trials Registry ID: UMIN000001676).Results Sixty-four subjects developed metachronous ESCC. A receiver operating characteristic curve showed that HRA scores ô12 best predicted the development of metachronous ESCC. The ESCC detection rate per 100 person-years was 9.8 in the high-HRA-score group (n = 104) and 4.5 in the low-HRA-score group (n = 174), and the risk of development of metachronous ESCC was higher in the high-HRA-score group than in the low-HRA-score group (adjusted hazard ratio: 2.00 [95% CI: 1.12-3.30]). Multiple LVLs was a very strong predictor of the development of metachronous SCC, but high HRA scores predicted it independently. The cumulative incidences of metachronous ESCC decreased after drinking cessation in the high-HRA-score drinker group (adjusted hazard ratio: 0.37 [0.14-0.97]). Conclusions Both the HRA model that included alcohol flushing and the multiple LVL grade predicted the development of metachronous ESCC in Japanese men after endoscopic mucosectomy for ESCC. Drinking cessation in the high-HRA-score drinker group reduced the rate of metachronous ESCC.

AB - Background Alcohol consumption combined with inactive aldehyde dehydrogenase-2 (ALDH2) and the presence of multiple esophageal Lugol-voiding lesions (LVLs; dysplasia) are strong predictors for multiple development of esophageal squamous cell carcinoma (ESCC) in East Asians. We invented a health risk appraisal (HRA) model for predicting the risk of ESCC based on drinking, smoking, dietary habits, and alcohol flushing, i.e., past or present facial flushing after drinking a glass of beer, a surrogate marker for inactive ALDH2. Methods Prospective follow-up examinations (median follow-up time, 50.3 months) were performed in 278 Japanese men after endoscopic mucosectomy for early ESCC (UMIN Clinical Trials Registry ID: UMIN000001676).Results Sixty-four subjects developed metachronous ESCC. A receiver operating characteristic curve showed that HRA scores ô12 best predicted the development of metachronous ESCC. The ESCC detection rate per 100 person-years was 9.8 in the high-HRA-score group (n = 104) and 4.5 in the low-HRA-score group (n = 174), and the risk of development of metachronous ESCC was higher in the high-HRA-score group than in the low-HRA-score group (adjusted hazard ratio: 2.00 [95% CI: 1.12-3.30]). Multiple LVLs was a very strong predictor of the development of metachronous SCC, but high HRA scores predicted it independently. The cumulative incidences of metachronous ESCC decreased after drinking cessation in the high-HRA-score drinker group (adjusted hazard ratio: 0.37 [0.14-0.97]). Conclusions Both the HRA model that included alcohol flushing and the multiple LVL grade predicted the development of metachronous ESCC in Japanese men after endoscopic mucosectomy for ESCC. Drinking cessation in the high-HRA-score drinker group reduced the rate of metachronous ESCC.

UR - http://www.scopus.com/inward/record.url?scp=85017187014&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017187014&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0175182

DO - 10.1371/journal.pone.0175182

M3 - Article

VL - 12

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 4

M1 - e0175182

ER -