Alcohol and aldehyde dehydrogenase genotypes in Korsakoff syndrome

Sachio Matsushita, Motoichiro Kato, Taro Muramatsu, Susumu Higuchi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Previous studies have suggested a genetic predisposition to the development of Wernicke-Korsakoff syndrome (WKS), a neuropsychiatric syndrome commonly associated with alcoholism; however, little is known about this genetic risk factor. Methods: To test the hypothesis that altered alcohol or aldehyde regulation is related to the development of WKS, the genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2) and alcohol dehydrogenase-2 (ADH2) were examined in 47 alcoholic subjects with WKS and compared with those of 342 alcoholic subjects without any WKS symptoms and 175 nonalcoholic controls. Results: Although the frequencies of the ALDH2 genotypes and alleles did not differ significantly between alcoholic subjects with WKS and alcoholics without WKS, the ADH2*1/2*1 genotype and ADH2*1 allele were significantly increased in WKS. Conclusions: These findings suggest that the ADH2*1/2*1 genotype is a risk factor for the development of WKS in alcoholic patients.

Original languageEnglish
Pages (from-to)337-340
Number of pages4
JournalAlcoholism: Clinical and Experimental Research
Volume24
Issue number3
Publication statusPublished - 2000 Mar

Fingerprint

Korsakoff Syndrome
Aldehyde Dehydrogenase
Alcohol Dehydrogenase
Genotype
Alcoholics
Polymorphism
Aldehydes
Alleles
Alcohols
Genetic Polymorphisms
Genetic Predisposition to Disease
Alcoholism

Keywords

  • Alcohol Dehydrogenase
  • Aldehyde Dehydrogenase
  • Genotypes
  • Risk Factors
  • Wernicke-Korsakoff Syndrome

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Alcohol and aldehyde dehydrogenase genotypes in Korsakoff syndrome. / Matsushita, Sachio; Kato, Motoichiro; Muramatsu, Taro; Higuchi, Susumu.

In: Alcoholism: Clinical and Experimental Research, Vol. 24, No. 3, 03.2000, p. 337-340.

Research output: Contribution to journalArticle

Matsushita, Sachio ; Kato, Motoichiro ; Muramatsu, Taro ; Higuchi, Susumu. / Alcohol and aldehyde dehydrogenase genotypes in Korsakoff syndrome. In: Alcoholism: Clinical and Experimental Research. 2000 ; Vol. 24, No. 3. pp. 337-340.
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