TY - JOUR
T1 - Alcohol consumption and cognitive function in elderly Japanese men
AU - for the SESSA Research Group
AU - Siddiquee, Ali Tanweer
AU - Kadota, Aya
AU - Fujiyoshi, Akira
AU - Miyagawa, Naoko
AU - Saito, Yoshino
AU - Suzuki, Harumitsu
AU - Kondo, Keiko
AU - Yamauchi, Hiromi
AU - Ito, Takahiro
AU - Segawa, Hiroyoshi
AU - Tooyama, Ikuo
AU - Miura, Katsuyuki
AU - Ueshima, Hirotsugu
N1 - Funding Information:
The SESSA (Shiga Epidemiological Study of Subclinical Atherosclerosis) has been supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number JP13307016 , JP17209023 , JP21249043 , JP23249036 , JP25253046 , JP15H02528 , JP18H04074 , JP23590790 , JP19H03898 from the Ministry of Education, Culture, Sports, Science, and Technology Japan , and by grant, R01HL068200 from the National Institute of Health (NIH) , USA and from Glaxo-Smith Kline GB . The present study was planned and analyzed by the authors. The funders had no role in the study design, data collection and analysis, interpretation of results, the decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/6
Y1 - 2020/6
N2 - Although heavy alcohol consumption has been identified as a risk factor for adverse cognitive functioning, it currently remains unclear whether moderate alcohol consumption exerts similar effects. Observational studies previously reported the potential benefits of moderate alcohol consumption on cognition, particularly in the elderly; however, these effects have not yet been demonstrated in Asian populations. The aim of the present study was to investigate the relationship between alcohol consumption levels and global and domain-specific cognitive functions in cognitively intact elderly Japanese men. Cross-sectional data from the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA), an ongoing prospective, population-based study in Shiga, Japan, were used to examine the relationship between alcohol consumption and cognitive function. Men (n = 585) aged ≥65 years provided information on their weekly consumption of alcohol, and the data obtained were used to construct categories of never, ex- (quit before interview), very light (<14 g/day), light (14–23 g/day), moderate (>23–46 g/day), and heavy (>46 g/day) drinkers. Cognitive function was measured using the Cognitive Abilities Screening Instrument (CASI). A fractional logistic regression model adjusted for age, education, body mass index, smoking, exercise, hypertension, diabetes, and dyslipidemia showed that the CASI scores for global and domain-specific cognitive functions were not significantly different between all subgroups of current drinkers and never-drinkers. However, the CASI score of ex-drinkers (multivariable adjusted mean CASI score [SD]) was significantly lower than that of never-drinkers in the global [never vs. ex: 90.16 (2.21) vs. 88.26 (2.58)] and abstraction and judgment domain [never vs. ex: 9.48 (0.46) vs. 8.61 (0.57)]). The present results do not suggest any beneficial or adverse relationship between current alcohol consumption levels and cognitive functioning (both global and domain specific) in elderly Japanese men; however, low cognitive function among ex-drinkers warrants future investigations to identify the factors causing drinkers to quit.
AB - Although heavy alcohol consumption has been identified as a risk factor for adverse cognitive functioning, it currently remains unclear whether moderate alcohol consumption exerts similar effects. Observational studies previously reported the potential benefits of moderate alcohol consumption on cognition, particularly in the elderly; however, these effects have not yet been demonstrated in Asian populations. The aim of the present study was to investigate the relationship between alcohol consumption levels and global and domain-specific cognitive functions in cognitively intact elderly Japanese men. Cross-sectional data from the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA), an ongoing prospective, population-based study in Shiga, Japan, were used to examine the relationship between alcohol consumption and cognitive function. Men (n = 585) aged ≥65 years provided information on their weekly consumption of alcohol, and the data obtained were used to construct categories of never, ex- (quit before interview), very light (<14 g/day), light (14–23 g/day), moderate (>23–46 g/day), and heavy (>46 g/day) drinkers. Cognitive function was measured using the Cognitive Abilities Screening Instrument (CASI). A fractional logistic regression model adjusted for age, education, body mass index, smoking, exercise, hypertension, diabetes, and dyslipidemia showed that the CASI scores for global and domain-specific cognitive functions were not significantly different between all subgroups of current drinkers and never-drinkers. However, the CASI score of ex-drinkers (multivariable adjusted mean CASI score [SD]) was significantly lower than that of never-drinkers in the global [never vs. ex: 90.16 (2.21) vs. 88.26 (2.58)] and abstraction and judgment domain [never vs. ex: 9.48 (0.46) vs. 8.61 (0.57)]). The present results do not suggest any beneficial or adverse relationship between current alcohol consumption levels and cognitive functioning (both global and domain specific) in elderly Japanese men; however, low cognitive function among ex-drinkers warrants future investigations to identify the factors causing drinkers to quit.
KW - Alcohol
KW - Cognitive function
KW - Elderly
KW - General population
KW - Japanese
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UR - http://www.scopus.com/inward/citedby.url?scp=85083338870&partnerID=8YFLogxK
U2 - 10.1016/j.alcohol.2020.01.001
DO - 10.1016/j.alcohol.2020.01.001
M3 - Article
C2 - 31923561
AN - SCOPUS:85083338870
SN - 0741-8329
VL - 85
SP - 145
EP - 152
JO - Alcohol
JF - Alcohol
ER -
