Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics

Akira Yokoyama, Taro Muramatsu, Tai Ohmori, Tetsuji Yokoyama, Keiji Okuyama, Hisao Takahashi, Yoshio Hasegawa, Susumu Higuchi, Katsuya Maruyama, Katsuyuki Shirakura, Hiromasa Ishii

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Abstract

Aldehyde dehydrogenase-2 (ALDH2) eliminates most of the acetaldehyde produced during alcohol metabolism. In some drinkers, a mutant ALDH2 allele contributes to diminished activity of the enzyme, dramatically increasing the risk for esophageal cancer. This study was designed to evaluate the ALDH2 gene polymorphism as a predictor of the development of cancers prevalent in Japanese alcoholics. We performed ALDH2 genotyping on lymphocyte DNA samples from Japanese alcoholic men (487 cancer-free; 237 with cancer, including 34 oropharyngolaryngeal, 87 esophageal, 58 stomach, 46 colon, 18 liver, 7 lung, 9 other sites, and 19 multiple primary cancers in two or three organs). The frequencies of the mutant ALDH2*2 allele were significantly higher in alcoholics with oropharyngo-laryngeal (52.9%), esophageal (52.9%), stomach (22.4%), colon (21.7%) and esophageal cancer concomitant with oropharyngolaryngeal and/or stomach cancer (78.6%), than in cancer-free alcoholics (9.0%). After adjustment for age, daily alcohol consumption and amount of cigarette smoking, significantly increased risks (odds ratios) in the presence of the ALDH2*2 allele were found for oropharyngolaryngeal (11.14), esophageal (12.50), stomach (3.49), colon (3.35), lung (8.20) and esophageal cancer concomitant with oropharyngolaryngeal and/or stomach cancer (54.20) but not for liver or other cancers. These results suggest a general role of acetaldehyde, a recognized animal carcinogen, in the development of human cancers.

Original languageEnglish
Pages (from-to)1383-1387
Number of pages5
JournalCarcinogenesis
Volume19
Issue number8
DOIs
Publication statusPublished - 1998 Aug

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Aldehyde Dehydrogenase
Alcoholics
Alcohols
Esophageal Neoplasms
Neoplasms
Stomach
Acetaldehyde
Alleles
Stomach Neoplasms
Colon
Odds Ratio
Liver
Human Development
Alcohol Drinking
Carcinogens
Colonic Neoplasms
Lung Neoplasms
Smoking
Lymphocytes
Lung

ASJC Scopus subject areas

  • Cancer Research

Cite this

Yokoyama, A., Muramatsu, T., Ohmori, T., Yokoyama, T., Okuyama, K., Takahashi, H., ... Ishii, H. (1998). Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics. Carcinogenesis, 19(8), 1383-1387. https://doi.org/10.1093/carcin/19.8.1383

Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics. / Yokoyama, Akira; Muramatsu, Taro; Ohmori, Tai; Yokoyama, Tetsuji; Okuyama, Keiji; Takahashi, Hisao; Hasegawa, Yoshio; Higuchi, Susumu; Maruyama, Katsuya; Shirakura, Katsuyuki; Ishii, Hiromasa.

In: Carcinogenesis, Vol. 19, No. 8, 08.1998, p. 1383-1387.

Research output: Contribution to journalArticle

Yokoyama, A, Muramatsu, T, Ohmori, T, Yokoyama, T, Okuyama, K, Takahashi, H, Hasegawa, Y, Higuchi, S, Maruyama, K, Shirakura, K & Ishii, H 1998, 'Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics', Carcinogenesis, vol. 19, no. 8, pp. 1383-1387. https://doi.org/10.1093/carcin/19.8.1383
Yokoyama, Akira ; Muramatsu, Taro ; Ohmori, Tai ; Yokoyama, Tetsuji ; Okuyama, Keiji ; Takahashi, Hisao ; Hasegawa, Yoshio ; Higuchi, Susumu ; Maruyama, Katsuya ; Shirakura, Katsuyuki ; Ishii, Hiromasa. / Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics. In: Carcinogenesis. 1998 ; Vol. 19, No. 8. pp. 1383-1387.
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