Alcoholic liver disease and its relationship with metabolic syndrome

Hiromasa Ishii, Yoshinori Horie, Yoshiyuki Yamagishi, Hirotoshi Ebinuma

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Alcoholic liver disease (ALD), which occurs from chronic excessive drinking, progresses from initial alcoholic fatty liver to more advanced type such as alcoholic hepatitis, liver fibrosis, or liver cirrhosis when habitual drinking continues. In general, chance of liver cirrhosis increases after 20 years of chronic heavy drinking, but liver cirrhosis can occur in women after a shorter period of habitual drinking at a lower amount of alcohol. Alcoholic liver cirrhosis accounts for approximately 20% of all liver cirrhosis cases. The key treatment is abstinence or substantial cutting down on drinking; the prognosis is poor if the patient continues drinking after being diagnosed with liver cirrhosis. Factors that exert adverse effects on the progression of ALD include gender difference, presence of hepatitis virus, immunologic abnormality, genetic polymorphism of alcohol-metabolizing enzymes, and complication of obesity or overweight. Recently, particular attention has been paid to obesity and overweight as risk factors in the progression of ALD. Conditions such as visceral fat accumulation, obesity, and diabetes mellitus underlie the pathologic factor of metabolic syndrome (MetS). In liver, MetS may accompany fatty liver or steatohepatitis, with possible progression to liver cirrhosis in some cases. Caution is required for patients with MetS who have a high alcohol intake because alcohol consumption further accelerates the progression of liver lesions.

Original languageEnglish
Pages (from-to)236-242
Number of pages7
JournalJapan Medical Association Journal
Volume53
Issue number4
Publication statusPublished - 2010 Jul

Fingerprint

Alcoholic Liver Diseases
Liver Cirrhosis
Drinking
Obesity
Alcohols
Fatty Liver
Alcoholic Fatty Liver
Alcoholic Hepatitis
Alcoholic Liver Cirrhosis
Hepatitis Viruses
Intra-Abdominal Fat
Liver
Genetic Polymorphisms
Alcohol Drinking
Diabetes Mellitus
Enzymes

Keywords

  • Alcoholic liver disease
  • Metabolic syndrome
  • NAFLD/NASH
  • Obesity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ishii, H., Horie, Y., Yamagishi, Y., & Ebinuma, H. (2010). Alcoholic liver disease and its relationship with metabolic syndrome. Japan Medical Association Journal, 53(4), 236-242.

Alcoholic liver disease and its relationship with metabolic syndrome. / Ishii, Hiromasa; Horie, Yoshinori; Yamagishi, Yoshiyuki; Ebinuma, Hirotoshi.

In: Japan Medical Association Journal, Vol. 53, No. 4, 07.2010, p. 236-242.

Research output: Contribution to journalArticle

Ishii, H, Horie, Y, Yamagishi, Y & Ebinuma, H 2010, 'Alcoholic liver disease and its relationship with metabolic syndrome', Japan Medical Association Journal, vol. 53, no. 4, pp. 236-242.
Ishii H, Horie Y, Yamagishi Y, Ebinuma H. Alcoholic liver disease and its relationship with metabolic syndrome. Japan Medical Association Journal. 2010 Jul;53(4):236-242.
Ishii, Hiromasa ; Horie, Yoshinori ; Yamagishi, Yoshiyuki ; Ebinuma, Hirotoshi. / Alcoholic liver disease and its relationship with metabolic syndrome. In: Japan Medical Association Journal. 2010 ; Vol. 53, No. 4. pp. 236-242.
@article{2b5b0d1f714540998253ca3b1b8cad29,
title = "Alcoholic liver disease and its relationship with metabolic syndrome",
abstract = "Alcoholic liver disease (ALD), which occurs from chronic excessive drinking, progresses from initial alcoholic fatty liver to more advanced type such as alcoholic hepatitis, liver fibrosis, or liver cirrhosis when habitual drinking continues. In general, chance of liver cirrhosis increases after 20 years of chronic heavy drinking, but liver cirrhosis can occur in women after a shorter period of habitual drinking at a lower amount of alcohol. Alcoholic liver cirrhosis accounts for approximately 20{\%} of all liver cirrhosis cases. The key treatment is abstinence or substantial cutting down on drinking; the prognosis is poor if the patient continues drinking after being diagnosed with liver cirrhosis. Factors that exert adverse effects on the progression of ALD include gender difference, presence of hepatitis virus, immunologic abnormality, genetic polymorphism of alcohol-metabolizing enzymes, and complication of obesity or overweight. Recently, particular attention has been paid to obesity and overweight as risk factors in the progression of ALD. Conditions such as visceral fat accumulation, obesity, and diabetes mellitus underlie the pathologic factor of metabolic syndrome (MetS). In liver, MetS may accompany fatty liver or steatohepatitis, with possible progression to liver cirrhosis in some cases. Caution is required for patients with MetS who have a high alcohol intake because alcohol consumption further accelerates the progression of liver lesions.",
keywords = "Alcoholic liver disease, Metabolic syndrome, NAFLD/NASH, Obesity",
author = "Hiromasa Ishii and Yoshinori Horie and Yoshiyuki Yamagishi and Hirotoshi Ebinuma",
year = "2010",
month = "7",
language = "English",
volume = "53",
pages = "236--242",
journal = "Asian Medical Journal",
issn = "1346-8650",
publisher = "Japan Medical Association",
number = "4",

}

TY - JOUR

T1 - Alcoholic liver disease and its relationship with metabolic syndrome

AU - Ishii, Hiromasa

AU - Horie, Yoshinori

AU - Yamagishi, Yoshiyuki

AU - Ebinuma, Hirotoshi

PY - 2010/7

Y1 - 2010/7

N2 - Alcoholic liver disease (ALD), which occurs from chronic excessive drinking, progresses from initial alcoholic fatty liver to more advanced type such as alcoholic hepatitis, liver fibrosis, or liver cirrhosis when habitual drinking continues. In general, chance of liver cirrhosis increases after 20 years of chronic heavy drinking, but liver cirrhosis can occur in women after a shorter period of habitual drinking at a lower amount of alcohol. Alcoholic liver cirrhosis accounts for approximately 20% of all liver cirrhosis cases. The key treatment is abstinence or substantial cutting down on drinking; the prognosis is poor if the patient continues drinking after being diagnosed with liver cirrhosis. Factors that exert adverse effects on the progression of ALD include gender difference, presence of hepatitis virus, immunologic abnormality, genetic polymorphism of alcohol-metabolizing enzymes, and complication of obesity or overweight. Recently, particular attention has been paid to obesity and overweight as risk factors in the progression of ALD. Conditions such as visceral fat accumulation, obesity, and diabetes mellitus underlie the pathologic factor of metabolic syndrome (MetS). In liver, MetS may accompany fatty liver or steatohepatitis, with possible progression to liver cirrhosis in some cases. Caution is required for patients with MetS who have a high alcohol intake because alcohol consumption further accelerates the progression of liver lesions.

AB - Alcoholic liver disease (ALD), which occurs from chronic excessive drinking, progresses from initial alcoholic fatty liver to more advanced type such as alcoholic hepatitis, liver fibrosis, or liver cirrhosis when habitual drinking continues. In general, chance of liver cirrhosis increases after 20 years of chronic heavy drinking, but liver cirrhosis can occur in women after a shorter period of habitual drinking at a lower amount of alcohol. Alcoholic liver cirrhosis accounts for approximately 20% of all liver cirrhosis cases. The key treatment is abstinence or substantial cutting down on drinking; the prognosis is poor if the patient continues drinking after being diagnosed with liver cirrhosis. Factors that exert adverse effects on the progression of ALD include gender difference, presence of hepatitis virus, immunologic abnormality, genetic polymorphism of alcohol-metabolizing enzymes, and complication of obesity or overweight. Recently, particular attention has been paid to obesity and overweight as risk factors in the progression of ALD. Conditions such as visceral fat accumulation, obesity, and diabetes mellitus underlie the pathologic factor of metabolic syndrome (MetS). In liver, MetS may accompany fatty liver or steatohepatitis, with possible progression to liver cirrhosis in some cases. Caution is required for patients with MetS who have a high alcohol intake because alcohol consumption further accelerates the progression of liver lesions.

KW - Alcoholic liver disease

KW - Metabolic syndrome

KW - NAFLD/NASH

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=77958460521&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77958460521&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:77958460521

VL - 53

SP - 236

EP - 242

JO - Asian Medical Journal

JF - Asian Medical Journal

SN - 1346-8650

IS - 4

ER -