TY - JOUR
T1 - Alkaloids from aerial parts of Annona senegalensis against Streptococcus mutans
AU - Lall, N.
AU - Kishore, N.
AU - Bodiba, D.
AU - More, G.
AU - Tshikalange, E.
AU - Kikuchi, H.
AU - Oshima, Y.
N1 - Funding Information:
This work was supported by the South African Agency for Science and Technology Advancement [grant number N00117]; University of Pretoria; National Research Foundation (NRF).
Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017
Y1 - 2017
N2 - Antimicrobial potential of medicinal plants have been explored extensively these days. This study was carried out to evaluate the antibacterial potential from aerial parts of plant, called ‘Annona senegalensis’ and its constituents. Bioassay guided fractionation led to the isolation of four metabolites, (+)-catechin (1), (−)-anonaine (2), (−)-asimilobine (3) and (+)-nornantenine (4). This is the first report on the isolation of compounds 1, 3 and 4 from this plant. Compounds 2 and 4 showed good activity, whereas 1 and 3 displayed weak inhibition against Streptococcus mutans (ATCC 25175). The results showed that compound 2 and 3 showed significant activity with a minimum inhibition concentration (MIC) of 0.12 and 0.25 mg/mL, respectively. The present study reports for the first time the antibacterial activity of the extract of A. senegalensis and its constituents. As S. mutans is a rather resistant bacteria, the MIC obtained during the present study is significant.
AB - Antimicrobial potential of medicinal plants have been explored extensively these days. This study was carried out to evaluate the antibacterial potential from aerial parts of plant, called ‘Annona senegalensis’ and its constituents. Bioassay guided fractionation led to the isolation of four metabolites, (+)-catechin (1), (−)-anonaine (2), (−)-asimilobine (3) and (+)-nornantenine (4). This is the first report on the isolation of compounds 1, 3 and 4 from this plant. Compounds 2 and 4 showed good activity, whereas 1 and 3 displayed weak inhibition against Streptococcus mutans (ATCC 25175). The results showed that compound 2 and 3 showed significant activity with a minimum inhibition concentration (MIC) of 0.12 and 0.25 mg/mL, respectively. The present study reports for the first time the antibacterial activity of the extract of A. senegalensis and its constituents. As S. mutans is a rather resistant bacteria, the MIC obtained during the present study is significant.
KW - Annona senegalensis
KW - Streptococcus mutans (ATCC 25175)
KW - alkaloids
KW - antibacterial activity
KW - flavonoids
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U2 - 10.1080/14786419.2016.1263847
DO - 10.1080/14786419.2016.1263847
M3 - Article
C2 - 27984920
AN - SCOPUS:85006285305
SN - 1478-6419
VL - 31
SP - 1944
EP - 1947
JO - Natural Product Research
JF - Natural Product Research
IS - 16
ER -