Alkaloids from aerial parts of Annona senegalensis against Streptococcus mutans

N. Lall, N. Kishore, D. Bodiba, G. More, E. Tshikalange, H. Kikuchi, Y. Oshima

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Antimicrobial potential of medicinal plants have been explored extensively these days. This study was carried out to evaluate the antibacterial potential from aerial parts of plant, called ‘Annona senegalensis’ and its constituents. Bioassay guided fractionation led to the isolation of four metabolites, (+)-catechin (1), (−)-anonaine (2), (−)-asimilobine (3) and (+)-nornantenine (4). This is the first report on the isolation of compounds 1, 3 and 4 from this plant. Compounds 2 and 4 showed good activity, whereas 1 and 3 displayed weak inhibition against Streptococcus mutans (ATCC 25175). The results showed that compound 2 and 3 showed significant activity with a minimum inhibition concentration (MIC) of 0.12 and 0.25 mg/mL, respectively. The present study reports for the first time the antibacterial activity of the extract of A. senegalensis and its constituents. As S. mutans is a rather resistant bacteria, the MIC obtained during the present study is significant.

Original languageEnglish
Pages (from-to)1944-1947
Number of pages4
JournalNatural Product Research
Volume31
Issue number16
DOIs
Publication statusPublished - 2017
Externally publishedYes

Keywords

  • Annona senegalensis
  • Streptococcus mutans (ATCC 25175)
  • alkaloids
  • antibacterial activity
  • flavonoids

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Alkaloids from aerial parts of Annona senegalensis against Streptococcus mutans'. Together they form a unique fingerprint.

Cite this