TY - JOUR
T1 - All-nanofiber-based, ultrasensitive, gas-permeable mechanoacoustic sensors for continuous long-term heart monitoring
AU - Nayeem, Md Osman Goni
AU - Lee, Sunghoon
AU - Jin, Hanbit
AU - Matsuhisa, Naoji
AU - Jinno, Hiroaki
AU - Miyamoto, Akihito
AU - Yokota, Tomoyuki
AU - Someya, Takao
N1 - Funding Information:
ACKNOWLEDGMENTS. This work was financially supported by the Japan Science and Technology ACCEL (Grant JPMJMI17F1), Japan. M.O.G.N. was supported by World-leading Innovative Graduate Study Program innovations for Future Society. The authors would like to express their gratitude to Dr. David D. Ordinario, Dr. Robert A. Nawrocki, and Dr. Simiao Niu for helpful scientific discussions and technical advice.
Publisher Copyright:
© 2020 National Academy of Sciences. All rights reserved.
PY - 2020/3/31
Y1 - 2020/3/31
N2 - The prolonged and continuous monitoring of mechanoacoustic heart signals is essential for the early diagnosis of cardiovascular diseases. These bodily acoustics have low intensity and low frequency, and measuring them continuously for long periods requires ultrasensitive, lightweight, gas-permeable mechanoacoustic sensors. Here, we present an all-nanofiber mechanoacoustic sensor, which exhibits a sensitivity as high as 10,050.6 mV Pa-1 in the lowfrequency region (<500 Hz). The high sensitivity is achieved by the use of durable and ultrathin (2.5 μm) nanofiber electrode layers enabling a large vibration of the sensor during the application of sound waves. The sensor is ultralightweight, and the overall weight is as small as 5 mg or less. The devices are mechanically robust against bending, and show no degradation in performance even after 1,000- cycle bending. Finally, we demonstrate a continuous long-term (10 h) measurement of heart signals with a signal-to-noise ratio as high as 40.9 decibels (dB).
AB - The prolonged and continuous monitoring of mechanoacoustic heart signals is essential for the early diagnosis of cardiovascular diseases. These bodily acoustics have low intensity and low frequency, and measuring them continuously for long periods requires ultrasensitive, lightweight, gas-permeable mechanoacoustic sensors. Here, we present an all-nanofiber mechanoacoustic sensor, which exhibits a sensitivity as high as 10,050.6 mV Pa-1 in the lowfrequency region (<500 Hz). The high sensitivity is achieved by the use of durable and ultrathin (2.5 μm) nanofiber electrode layers enabling a large vibration of the sensor during the application of sound waves. The sensor is ultralightweight, and the overall weight is as small as 5 mg or less. The devices are mechanically robust against bending, and show no degradation in performance even after 1,000- cycle bending. Finally, we demonstrate a continuous long-term (10 h) measurement of heart signals with a signal-to-noise ratio as high as 40.9 decibels (dB).
KW - Biomedical devices
KW - Gas-permeable sensors
KW - Mechanoacoustic sensor
KW - Wearable electronics
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U2 - 10.1073/pnas.1920911117
DO - 10.1073/pnas.1920911117
M3 - Article
C2 - 32188781
AN - SCOPUS:85082758137
SN - 0027-8424
VL - 117
SP - 7063
EP - 7070
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 13
ER -
