Allergic bronchopulmonary aspergillosis in Japan

A nationwide survey

Tsuyoshi Oguma, Masami Taniguchi, Terufumi Shimoda, Katsuhiko Kamei, Hiroto Matsuse, Akira Hebisawa, Noboru Takayanagi, Satoshi Konno, Koichi Fukunaga, Kazuki Harada, Jun Tanaka, Katsuyoshi Tomomatsu, Koichiro Asano

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Allergic bronchopulmonary aspergillosis (ABPA) is an allergic pulmonary disease characterized by a hypersensitivity reaction to Aspergillus species colonizing the airways. The clinical characteristics of ABPA may differ depending on genetic and environmental background. We performed a nationwide survey to determine the clinical characteristics of ABPA in Japan. Methods: In 2013, a questionnaire on physician-diagnosed ABPA/allergic bronchopulmonary mycosis was sent to 903 medical centers specializing in respiratory or allergic diseases. Cases fulfilling the following criteria were categorized as possible ABPA-central bronchiectasis (ABPA-CB): 1) presence of specific serum immunoglobulin E (IgE) antibodies or a positive skin reaction to Aspergillus, and 2) bronchiectasis or mucoid impaction in the central bronchi. Results: Of 499 physician-diagnosed cases reported by 132 clinical centers, 358 cases met the criteria for possible ABPA-CB. Median age of ABPA-CB onset was 57 (interquartile range, 44-68) years; later-onset disease, developing ≥50 years of age, accounted for 66% of the cases and was associated with female sex, delayed onset of asthma, and lower levels of serum IgE. A third of the patients (120 patients, 34%) exhibited low levels of serum total IgE (<1000 IU/mL). Aspergillus species were isolated from sputum in 126/213 cases (59%), and Schizophyllum commune was identified in 12 (6%) patients. During the course of the treatment, ABPA recurred in 169 (48%) cases. Conclusions: This nationwide survey identified several unique clinical characteristics of ABPA in Japan, such as late-onset, relatively lower serum IgE levels, and frequent recurrences/flares.

Original languageEnglish
JournalAllergology International
DOIs
Publication statusAccepted/In press - 2016 Dec 26

Fingerprint

Allergic Bronchopulmonary Aspergillosis
Japan
Immunoglobulin E
Aspergillus
Bronchiectasis
Serum
Schizophyllum
Invasive Pulmonary Aspergillosis
Physicians
Surveys and Questionnaires
Bronchi
Sputum
Lung Diseases
Hypersensitivity
Asthma
Recurrence

Keywords

  • Allergic bronchopulmonary aspergillosis
  • Aspergillus
  • Bronchiectasis
  • Immunoglobulin E
  • Schizophyllum commune

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Oguma, T., Taniguchi, M., Shimoda, T., Kamei, K., Matsuse, H., Hebisawa, A., ... Asano, K. (Accepted/In press). Allergic bronchopulmonary aspergillosis in Japan: A nationwide survey. Allergology International. https://doi.org/10.1016/j.alit.2017.04.011

Allergic bronchopulmonary aspergillosis in Japan : A nationwide survey. / Oguma, Tsuyoshi; Taniguchi, Masami; Shimoda, Terufumi; Kamei, Katsuhiko; Matsuse, Hiroto; Hebisawa, Akira; Takayanagi, Noboru; Konno, Satoshi; Fukunaga, Koichi; Harada, Kazuki; Tanaka, Jun; Tomomatsu, Katsuyoshi; Asano, Koichiro.

In: Allergology International, 26.12.2016.

Research output: Contribution to journalArticle

Oguma, T, Taniguchi, M, Shimoda, T, Kamei, K, Matsuse, H, Hebisawa, A, Takayanagi, N, Konno, S, Fukunaga, K, Harada, K, Tanaka, J, Tomomatsu, K & Asano, K 2016, 'Allergic bronchopulmonary aspergillosis in Japan: A nationwide survey', Allergology International. https://doi.org/10.1016/j.alit.2017.04.011
Oguma, Tsuyoshi ; Taniguchi, Masami ; Shimoda, Terufumi ; Kamei, Katsuhiko ; Matsuse, Hiroto ; Hebisawa, Akira ; Takayanagi, Noboru ; Konno, Satoshi ; Fukunaga, Koichi ; Harada, Kazuki ; Tanaka, Jun ; Tomomatsu, Katsuyoshi ; Asano, Koichiro. / Allergic bronchopulmonary aspergillosis in Japan : A nationwide survey. In: Allergology International. 2016.
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abstract = "Background: Allergic bronchopulmonary aspergillosis (ABPA) is an allergic pulmonary disease characterized by a hypersensitivity reaction to Aspergillus species colonizing the airways. The clinical characteristics of ABPA may differ depending on genetic and environmental background. We performed a nationwide survey to determine the clinical characteristics of ABPA in Japan. Methods: In 2013, a questionnaire on physician-diagnosed ABPA/allergic bronchopulmonary mycosis was sent to 903 medical centers specializing in respiratory or allergic diseases. Cases fulfilling the following criteria were categorized as possible ABPA-central bronchiectasis (ABPA-CB): 1) presence of specific serum immunoglobulin E (IgE) antibodies or a positive skin reaction to Aspergillus, and 2) bronchiectasis or mucoid impaction in the central bronchi. Results: Of 499 physician-diagnosed cases reported by 132 clinical centers, 358 cases met the criteria for possible ABPA-CB. Median age of ABPA-CB onset was 57 (interquartile range, 44-68) years; later-onset disease, developing ≥50 years of age, accounted for 66{\%} of the cases and was associated with female sex, delayed onset of asthma, and lower levels of serum IgE. A third of the patients (120 patients, 34{\%}) exhibited low levels of serum total IgE (<1000 IU/mL). Aspergillus species were isolated from sputum in 126/213 cases (59{\%}), and Schizophyllum commune was identified in 12 (6{\%}) patients. During the course of the treatment, ABPA recurred in 169 (48{\%}) cases. Conclusions: This nationwide survey identified several unique clinical characteristics of ABPA in Japan, such as late-onset, relatively lower serum IgE levels, and frequent recurrences/flares.",
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T2 - A nationwide survey

AU - Oguma, Tsuyoshi

AU - Taniguchi, Masami

AU - Shimoda, Terufumi

AU - Kamei, Katsuhiko

AU - Matsuse, Hiroto

AU - Hebisawa, Akira

AU - Takayanagi, Noboru

AU - Konno, Satoshi

AU - Fukunaga, Koichi

AU - Harada, Kazuki

AU - Tanaka, Jun

AU - Tomomatsu, Katsuyoshi

AU - Asano, Koichiro

PY - 2016/12/26

Y1 - 2016/12/26

N2 - Background: Allergic bronchopulmonary aspergillosis (ABPA) is an allergic pulmonary disease characterized by a hypersensitivity reaction to Aspergillus species colonizing the airways. The clinical characteristics of ABPA may differ depending on genetic and environmental background. We performed a nationwide survey to determine the clinical characteristics of ABPA in Japan. Methods: In 2013, a questionnaire on physician-diagnosed ABPA/allergic bronchopulmonary mycosis was sent to 903 medical centers specializing in respiratory or allergic diseases. Cases fulfilling the following criteria were categorized as possible ABPA-central bronchiectasis (ABPA-CB): 1) presence of specific serum immunoglobulin E (IgE) antibodies or a positive skin reaction to Aspergillus, and 2) bronchiectasis or mucoid impaction in the central bronchi. Results: Of 499 physician-diagnosed cases reported by 132 clinical centers, 358 cases met the criteria for possible ABPA-CB. Median age of ABPA-CB onset was 57 (interquartile range, 44-68) years; later-onset disease, developing ≥50 years of age, accounted for 66% of the cases and was associated with female sex, delayed onset of asthma, and lower levels of serum IgE. A third of the patients (120 patients, 34%) exhibited low levels of serum total IgE (<1000 IU/mL). Aspergillus species were isolated from sputum in 126/213 cases (59%), and Schizophyllum commune was identified in 12 (6%) patients. During the course of the treatment, ABPA recurred in 169 (48%) cases. Conclusions: This nationwide survey identified several unique clinical characteristics of ABPA in Japan, such as late-onset, relatively lower serum IgE levels, and frequent recurrences/flares.

AB - Background: Allergic bronchopulmonary aspergillosis (ABPA) is an allergic pulmonary disease characterized by a hypersensitivity reaction to Aspergillus species colonizing the airways. The clinical characteristics of ABPA may differ depending on genetic and environmental background. We performed a nationwide survey to determine the clinical characteristics of ABPA in Japan. Methods: In 2013, a questionnaire on physician-diagnosed ABPA/allergic bronchopulmonary mycosis was sent to 903 medical centers specializing in respiratory or allergic diseases. Cases fulfilling the following criteria were categorized as possible ABPA-central bronchiectasis (ABPA-CB): 1) presence of specific serum immunoglobulin E (IgE) antibodies or a positive skin reaction to Aspergillus, and 2) bronchiectasis or mucoid impaction in the central bronchi. Results: Of 499 physician-diagnosed cases reported by 132 clinical centers, 358 cases met the criteria for possible ABPA-CB. Median age of ABPA-CB onset was 57 (interquartile range, 44-68) years; later-onset disease, developing ≥50 years of age, accounted for 66% of the cases and was associated with female sex, delayed onset of asthma, and lower levels of serum IgE. A third of the patients (120 patients, 34%) exhibited low levels of serum total IgE (<1000 IU/mL). Aspergillus species were isolated from sputum in 126/213 cases (59%), and Schizophyllum commune was identified in 12 (6%) patients. During the course of the treatment, ABPA recurred in 169 (48%) cases. Conclusions: This nationwide survey identified several unique clinical characteristics of ABPA in Japan, such as late-onset, relatively lower serum IgE levels, and frequent recurrences/flares.

KW - Allergic bronchopulmonary aspergillosis

KW - Aspergillus

KW - Bronchiectasis

KW - Immunoglobulin E

KW - Schizophyllum commune

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