Allogeneic haematopoietic stem cell transplantation for the treatment of adult T-cell leukaemia/lymphoma

Masahiro Kami, Tamae Hamaki, Shigesaburo Miyakoshi, Naoko Murashige, Yoshinobu Kanda, Ryuji Tanosaki, Yoichi Takaue, Shuichi Taniguchi, Hisamaru Hirai, Keiya Ozawa, Masaharu Kasai

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78 Citations (Scopus)

Abstract

The feasibility of allogeneic haematopoietic stem-cell transplantation (allo-HSCT) in 11 patients with adult T-cell leukaemia/lymphoma (ATL) (6 acute, 4 lymphoma, 1 chronic type) was evaluated. The preparative regimens (9 conventional, 2 reduced-intensity) were tolerable. Five patients developed acute graft-versus-host disease (GVHD), and three, extensive chronic GVHD. All 10 patients who survived > 30 d achieved complete remission. Estimated 1-year overall and disease-free survival rates were 53 ± 30% and 45 ± 29% respectively. Four patients remain alive and disease-free at a median follow-up of 25 months. The others died of transplantation-related complications. This pilot study suggests that allo-HSCT in ATL should be evaluated further.

Original languageEnglish
Pages (from-to)304-309
Number of pages6
JournalBritish Journal of Haematology
Volume120
Issue number2
DOIs
Publication statusPublished - 2003 Jan 1
Externally publishedYes

Keywords

  • Adult T-cell leukaemia/lymphoma
  • Allogeneic haematopoietic stem-cell transplantation
  • Graft-versus-host disease
  • Graft-versus-leukaemia effect
  • Regimen-related toxicity

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Kami, M., Hamaki, T., Miyakoshi, S., Murashige, N., Kanda, Y., Tanosaki, R., Takaue, Y., Taniguchi, S., Hirai, H., Ozawa, K., & Kasai, M. (2003). Allogeneic haematopoietic stem cell transplantation for the treatment of adult T-cell leukaemia/lymphoma. British Journal of Haematology, 120(2), 304-309. https://doi.org/10.1046/j.1365-2141.2003.04054.x