Allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia--recent progress

Shinichiro Okamoto

Research output: Contribution to journalReview articlepeer-review

Abstract

Allogeneic stem cell transplantation represents the most active form of anti-leukemic therapy in acute myeloid leukemia (AML). Advances in the transplant technology, availability of hematopoietic stem cells and supportive care not only have resulted in improved outcomes but also expanded the transplant options. However, post-transplant relapse and transplant-related mortality, especially those associated with allo-immune reaction after transplantation, remain as the leading causes of failure of this therapeutic approach. This review is going to focus on the recent progress to selectively enhance the anti-AML activity of conditioning and post-transplant allo-immune reaction.

Original languageEnglish
Pages (from-to)1944-1950
Number of pages7
JournalNippon rinsho. Japanese journal of clinical medicine
Volume67
Issue number10
Publication statusPublished - 2009 Oct

ASJC Scopus subject areas

  • Medicine(all)

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