Allogeneic hematopoietic stem cell transplantation for patients with mildly reduced renal function as defined based on creatinine clearance before transplantation

Kumi Oshima, Yoshinobu Kanda, Yasuhito Nanya, Masatsugu Tanaka, Chiaki Nakaseko, Shingo Yano, Shin Fujisawa, Hiroyuki Fujita, Akira Yokota, Satoshi Takahashi, Heiwa Kanamori, Shinichiro Okamoto

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5 Citations (Scopus)

Abstract

While renal comorbidity is generally defined by the serum creatinine level, the creatinine clearance rate (Ccr) is a more accurate indicator of renal function. Therefore, we retrospectively assessed how mildly reduced renal function as defined based on Ccr affects the outcome after allogeneic hematopoietic stem cell transplantation (HSCT). Patients who underwent allogeneic HSCT at the eight institutes of the Kanto Study Group for Cell Therapy were included in this study. Based on the corrected Ccr, patients were classified into group 0 (n = 440, ≥ 90 mL/min/1.73 m2), group 1 (n = 56, 60-89 mL/min/1.73 m2), or group 2 (n = 11, 30-59 mL/min/1.73 m2). Therefore, 67 patients were considered to have mild renal impairment, whereas only 2 had a serum creatinine level higher than 1.2 mg/dL. Twenty-eight patients required hemodialysis after HSCT, with 5.5, 5.4, and 9.1 % in groups 0, 1, and 2, respectively (p = 0.65). The incidence of non-relapse mortality (NRM) was higher in group 2, although these differences were not statistically significant probably due to the small sample size (23.7, 28.2, and 47.2 % at 3 years, p = 0.20). In conclusion, NRM may be associated with mildly reduced renal function before allogeneic HSCT, which cannot be detected by measurement of the serum creatinine level alone.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalAnnals of Hematology
Volume92
Issue number2
DOIs
Publication statusPublished - 2013 Jan 1

Keywords

  • Chronic kidney disease
  • HSCT
  • Reduced renal function

ASJC Scopus subject areas

  • Hematology

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    Oshima, K., Kanda, Y., Nanya, Y., Tanaka, M., Nakaseko, C., Yano, S., Fujisawa, S., Fujita, H., Yokota, A., Takahashi, S., Kanamori, H., & Okamoto, S. (2013). Allogeneic hematopoietic stem cell transplantation for patients with mildly reduced renal function as defined based on creatinine clearance before transplantation. Annals of Hematology, 92(2), 255-260. https://doi.org/10.1007/s00277-012-1584-1