Abstract
While renal comorbidity is generally defined by the serum creatinine level, the creatinine clearance rate (Ccr) is a more accurate indicator of renal function. Therefore, we retrospectively assessed how mildly reduced renal function as defined based on Ccr affects the outcome after allogeneic hematopoietic stem cell transplantation (HSCT). Patients who underwent allogeneic HSCT at the eight institutes of the Kanto Study Group for Cell Therapy were included in this study. Based on the corrected Ccr, patients were classified into group 0 (n = 440, ≥ 90 mL/min/1.73 m2), group 1 (n = 56, 60-89 mL/min/1.73 m2), or group 2 (n = 11, 30-59 mL/min/1.73 m2). Therefore, 67 patients were considered to have mild renal impairment, whereas only 2 had a serum creatinine level higher than 1.2 mg/dL. Twenty-eight patients required hemodialysis after HSCT, with 5.5, 5.4, and 9.1 % in groups 0, 1, and 2, respectively (p = 0.65). The incidence of non-relapse mortality (NRM) was higher in group 2, although these differences were not statistically significant probably due to the small sample size (23.7, 28.2, and 47.2 % at 3 years, p = 0.20). In conclusion, NRM may be associated with mildly reduced renal function before allogeneic HSCT, which cannot be detected by measurement of the serum creatinine level alone.
| Original language | English |
|---|---|
| Pages (from-to) | 255-260 |
| Number of pages | 6 |
| Journal | Annals of Hematology |
| Volume | 92 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2013 Jan |
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Keywords
- Chronic kidney disease
- HSCT
- Reduced renal function
ASJC Scopus subject areas
- Hematology
Cite this
Allogeneic hematopoietic stem cell transplantation for patients with mildly reduced renal function as defined based on creatinine clearance before transplantation. / Oshima, Kumi; Kanda, Yoshinobu; Nanya, Yasuhito; Tanaka, Masatsugu; Nakaseko, Chiaki; Yano, Shingo; Fujisawa, Shin; Fujita, Hiroyuki; Yokota, Akira; Takahashi, Satoshi; Kanamori, Heiwa; Okamoto, Shinichiro.
In: Annals of Hematology, Vol. 92, No. 2, 01.2013, p. 255-260.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Allogeneic hematopoietic stem cell transplantation for patients with mildly reduced renal function as defined based on creatinine clearance before transplantation
AU - Oshima, Kumi
AU - Kanda, Yoshinobu
AU - Nanya, Yasuhito
AU - Tanaka, Masatsugu
AU - Nakaseko, Chiaki
AU - Yano, Shingo
AU - Fujisawa, Shin
AU - Fujita, Hiroyuki
AU - Yokota, Akira
AU - Takahashi, Satoshi
AU - Kanamori, Heiwa
AU - Okamoto, Shinichiro
PY - 2013/1
Y1 - 2013/1
N2 - While renal comorbidity is generally defined by the serum creatinine level, the creatinine clearance rate (Ccr) is a more accurate indicator of renal function. Therefore, we retrospectively assessed how mildly reduced renal function as defined based on Ccr affects the outcome after allogeneic hematopoietic stem cell transplantation (HSCT). Patients who underwent allogeneic HSCT at the eight institutes of the Kanto Study Group for Cell Therapy were included in this study. Based on the corrected Ccr, patients were classified into group 0 (n = 440, ≥ 90 mL/min/1.73 m2), group 1 (n = 56, 60-89 mL/min/1.73 m2), or group 2 (n = 11, 30-59 mL/min/1.73 m2). Therefore, 67 patients were considered to have mild renal impairment, whereas only 2 had a serum creatinine level higher than 1.2 mg/dL. Twenty-eight patients required hemodialysis after HSCT, with 5.5, 5.4, and 9.1 % in groups 0, 1, and 2, respectively (p = 0.65). The incidence of non-relapse mortality (NRM) was higher in group 2, although these differences were not statistically significant probably due to the small sample size (23.7, 28.2, and 47.2 % at 3 years, p = 0.20). In conclusion, NRM may be associated with mildly reduced renal function before allogeneic HSCT, which cannot be detected by measurement of the serum creatinine level alone.
AB - While renal comorbidity is generally defined by the serum creatinine level, the creatinine clearance rate (Ccr) is a more accurate indicator of renal function. Therefore, we retrospectively assessed how mildly reduced renal function as defined based on Ccr affects the outcome after allogeneic hematopoietic stem cell transplantation (HSCT). Patients who underwent allogeneic HSCT at the eight institutes of the Kanto Study Group for Cell Therapy were included in this study. Based on the corrected Ccr, patients were classified into group 0 (n = 440, ≥ 90 mL/min/1.73 m2), group 1 (n = 56, 60-89 mL/min/1.73 m2), or group 2 (n = 11, 30-59 mL/min/1.73 m2). Therefore, 67 patients were considered to have mild renal impairment, whereas only 2 had a serum creatinine level higher than 1.2 mg/dL. Twenty-eight patients required hemodialysis after HSCT, with 5.5, 5.4, and 9.1 % in groups 0, 1, and 2, respectively (p = 0.65). The incidence of non-relapse mortality (NRM) was higher in group 2, although these differences were not statistically significant probably due to the small sample size (23.7, 28.2, and 47.2 % at 3 years, p = 0.20). In conclusion, NRM may be associated with mildly reduced renal function before allogeneic HSCT, which cannot be detected by measurement of the serum creatinine level alone.
KW - Chronic kidney disease
KW - HSCT
KW - Reduced renal function
UR - http://www.scopus.com/inward/record.url?scp=84872285910&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872285910&partnerID=8YFLogxK
U2 - 10.1007/s00277-012-1584-1
DO - 10.1007/s00277-012-1584-1
M3 - Article
C2 - 23053182
AN - SCOPUS:84872285910
VL - 92
SP - 255
EP - 260
JO - Annals of Hematology
JF - Annals of Hematology
SN - 0939-5555
IS - 2
ER -