Allogeneic stem cell transplantation for adult Philadelphia chromosome-negative acute lymphocytic leukemia: Comparable survival rates but different risk factors between related and unrelated transplantation in first complete remission

Satoshi Nishiwaki, Yoshihiro Inamoto, Hisashi Sakamaki, Mineo Kurokawa, Hiroatsu Iida, Hiroyasu Ogawa, Takahiro Fukuda, Yukiyasu Ozawa, Naoki Kobayashi, Masanobu Kasai, Takehiko Mori, Koji Iwato, Takashi Yoshida, Makoto Onizuka, Keisei Kawa, Yasuo Morishima, Ritsuro Suzuki, Yoshiko Atsuta, Koichi Miyamura

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

To identify factors to improve the outcomes of related and unrelated allogeneic stem cell transplantations (allo-SCT) for Philadelphia chromosome-negative acute lymphocytic leukemia (Ph- ALL) in the first complete remission (CR1), we retrospectively analyzed 1139 Ph- ALL patients using the registry data, particularly the details of 641 patients transplanted in CR1. Overall survival was significantly superior among patients transplanted in CR1, but no significant difference was observed between related and unrelated allo-SCTs (related vs unrelated: 65% vs 62% at 4 years, respectively; P = .19). Among patients transplanted in CR1, relapse rates were significantly higher in related allo-SCT compared with unrelated allo-SCT, and multivariate analysis demonstrated that less than 6 months from diagnosis to allo-SCT alone was associated with relapse. On the other hand, nonrelapse mortality (NRM) was significantly higher in unrelated allo-SCT compared with related allo-SCT, and multivariate analysis demonstrated that 10 months or longer from diagnosis to allo-SCT, human leukocyte antigen mismatch, and abnormal karyotype were associated with NRM. In conclusion, our study showed comparable survival rates but different relapse rates, NRM rates, and risk factors between related and unrelated allo-SCTs. After a close consideration of these factors, the outcome of allo-SCT for adult Ph- ALL in CR1 could be improved.

Original languageEnglish
Pages (from-to)4368-4375
Number of pages8
JournalBlood
Volume116
Issue number20
DOIs
Publication statusPublished - 2010 Nov 18

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Philadelphia Chromosome
Stem Cell Transplantation
Chromosomes
Stem cells
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Survival Rate
Transplantation
Recurrence
Mortality
Multivariate Analysis
Abnormal Karyotype
HLA Antigens
Registries
Survival

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Allogeneic stem cell transplantation for adult Philadelphia chromosome-negative acute lymphocytic leukemia : Comparable survival rates but different risk factors between related and unrelated transplantation in first complete remission. / Nishiwaki, Satoshi; Inamoto, Yoshihiro; Sakamaki, Hisashi; Kurokawa, Mineo; Iida, Hiroatsu; Ogawa, Hiroyasu; Fukuda, Takahiro; Ozawa, Yukiyasu; Kobayashi, Naoki; Kasai, Masanobu; Mori, Takehiko; Iwato, Koji; Yoshida, Takashi; Onizuka, Makoto; Kawa, Keisei; Morishima, Yasuo; Suzuki, Ritsuro; Atsuta, Yoshiko; Miyamura, Koichi.

In: Blood, Vol. 116, No. 20, 18.11.2010, p. 4368-4375.

Research output: Contribution to journalArticle

Nishiwaki, S, Inamoto, Y, Sakamaki, H, Kurokawa, M, Iida, H, Ogawa, H, Fukuda, T, Ozawa, Y, Kobayashi, N, Kasai, M, Mori, T, Iwato, K, Yoshida, T, Onizuka, M, Kawa, K, Morishima, Y, Suzuki, R, Atsuta, Y & Miyamura, K 2010, 'Allogeneic stem cell transplantation for adult Philadelphia chromosome-negative acute lymphocytic leukemia: Comparable survival rates but different risk factors between related and unrelated transplantation in first complete remission', Blood, vol. 116, no. 20, pp. 4368-4375. https://doi.org/10.1182/blood-2010-02-269571
Nishiwaki, Satoshi ; Inamoto, Yoshihiro ; Sakamaki, Hisashi ; Kurokawa, Mineo ; Iida, Hiroatsu ; Ogawa, Hiroyasu ; Fukuda, Takahiro ; Ozawa, Yukiyasu ; Kobayashi, Naoki ; Kasai, Masanobu ; Mori, Takehiko ; Iwato, Koji ; Yoshida, Takashi ; Onizuka, Makoto ; Kawa, Keisei ; Morishima, Yasuo ; Suzuki, Ritsuro ; Atsuta, Yoshiko ; Miyamura, Koichi. / Allogeneic stem cell transplantation for adult Philadelphia chromosome-negative acute lymphocytic leukemia : Comparable survival rates but different risk factors between related and unrelated transplantation in first complete remission. In: Blood. 2010 ; Vol. 116, No. 20. pp. 4368-4375.
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abstract = "To identify factors to improve the outcomes of related and unrelated allogeneic stem cell transplantations (allo-SCT) for Philadelphia chromosome-negative acute lymphocytic leukemia (Ph- ALL) in the first complete remission (CR1), we retrospectively analyzed 1139 Ph- ALL patients using the registry data, particularly the details of 641 patients transplanted in CR1. Overall survival was significantly superior among patients transplanted in CR1, but no significant difference was observed between related and unrelated allo-SCTs (related vs unrelated: 65{\%} vs 62{\%} at 4 years, respectively; P = .19). Among patients transplanted in CR1, relapse rates were significantly higher in related allo-SCT compared with unrelated allo-SCT, and multivariate analysis demonstrated that less than 6 months from diagnosis to allo-SCT alone was associated with relapse. On the other hand, nonrelapse mortality (NRM) was significantly higher in unrelated allo-SCT compared with related allo-SCT, and multivariate analysis demonstrated that 10 months or longer from diagnosis to allo-SCT, human leukocyte antigen mismatch, and abnormal karyotype were associated with NRM. In conclusion, our study showed comparable survival rates but different relapse rates, NRM rates, and risk factors between related and unrelated allo-SCTs. After a close consideration of these factors, the outcome of allo-SCT for adult Ph- ALL in CR1 could be improved.",
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AU - Inamoto, Yoshihiro

AU - Sakamaki, Hisashi

AU - Kurokawa, Mineo

AU - Iida, Hiroatsu

AU - Ogawa, Hiroyasu

AU - Fukuda, Takahiro

AU - Ozawa, Yukiyasu

AU - Kobayashi, Naoki

AU - Kasai, Masanobu

AU - Mori, Takehiko

AU - Iwato, Koji

AU - Yoshida, Takashi

AU - Onizuka, Makoto

AU - Kawa, Keisei

AU - Morishima, Yasuo

AU - Suzuki, Ritsuro

AU - Atsuta, Yoshiko

AU - Miyamura, Koichi

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