Allogeneic unrelated bone marrow transplantation from older donors results in worse prognosis in recipients with aplastic anemia

Japan Society for Hematopoietic Cell Transplantation

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Allogeneic bone marrow transplantation is an essential therapy for acquired aplastic anemia and prognosis has recently improved. However, engraftment failure and graft-versus-host disease are potential fatal complications. Various risk factors for poor prognosis have been identified, such as patient age and human-leukocyte antigen disparity, but the relationship between donor age and prognosis is still unknown. Therefore, we performed a cohort study to compare the prognosis of unrelated bone marrow transplantation from younger and older donors using the registry database in Japan. We evaluated 427 patients (age 16-72 years) with aplastic anemia who underwent bone marrow transplantation from younger (≤39 years, n=281) or older (≥40 years, n=146) unrelated donors. Overall survival of the older donor group was significantly inferior to that of the younger donor group (adjusted hazard ratio 1.64; 95% confidence interval 1.15-2.35; P

Original languageEnglish
Pages (from-to)644-652
Number of pages9
JournalHaematologica
Volume101
Issue number5
DOIs
Publication statusPublished - 2016 Apr 30

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Aplastic Anemia
Bone Marrow Transplantation
Tissue Donors
Unrelated Donors
Homologous Transplantation
Graft vs Host Disease
HLA Antigens
Registries
Japan
Cohort Studies
Databases
Confidence Intervals
Survival
Therapeutics

ASJC Scopus subject areas

  • Hematology

Cite this

Allogeneic unrelated bone marrow transplantation from older donors results in worse prognosis in recipients with aplastic anemia. / Japan Society for Hematopoietic Cell Transplantation.

In: Haematologica, Vol. 101, No. 5, 30.04.2016, p. 644-652.

Research output: Contribution to journalArticle

Japan Society for Hematopoietic Cell Transplantation. / Allogeneic unrelated bone marrow transplantation from older donors results in worse prognosis in recipients with aplastic anemia. In: Haematologica. 2016 ; Vol. 101, No. 5. pp. 644-652.
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