Alteration of acidic lipids in human sera during the course of pregnancy: Characteristic increase in the concentration of cholesterol sulfate

Bei Lin, Kaneyuki Kubushiro, Yasuo Akiba, Yongxi Cui, Katsumi Tsukazaki, Shiro Nozawa, Masao Iwamori

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In this study, we determined the concentrations of acidic lipids, including cholesterol sulfate (CS), sulfatide and GM3 ganglioside, in human sera of non-pregnant state and during the course of pregnancy. In human sera of non-pregnant women, GM3 was present at a concentration of 8 nmol/ml and the concentrations of CS and sulfatides were less than 20% of that of GM3. The concentration of sulfatides in sera at the second trimester of gestation was decreased, but CS gradually increased from the first to the third trimester of gestation with a correlation coefficient of 0.66, and a correlation between the concentration of CS and weeks of gestation (p < 0.01). CS was also contained in the placental villi, and its concentration increased from the first to the third trimester of gestation, suggesting that placental CS is one of the source of CS in the blood by shedding.

Original languageEnglish
Pages (from-to)99-104
Number of pages6
JournalJournal of Chromatography B: Biomedical Applications
Volume704
Issue number1-2
DOIs
Publication statusPublished - 1997 Dec 19

Keywords

  • Cholesterol sulfate
  • GM3 ganglioside
  • Lipids
  • Sulfatide

ASJC Scopus subject areas

  • Chemistry(all)

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