Alteration of Ca²⁺ permeability and sensitivity to Mg²⁺ and channel blockers by a single amino acid substitution in the N-methyl-D-aspartate receptor

Medicine & Life Sciences

• NMDA receptor A1 100%
• Amino Acid Substitution 99%
• N-Methyl-D-Aspartate Receptors 92%
• Permeability 78%
• Asparagine 76%
• Dizocilpine Maleate 74%
• Desipramine 38%
• Mutation 34%
• Glutamate Receptors 33%
• Xenopus 32%
• Glutamine 32%
• Mutagenesis 30%
• Neuronal Plasticity 29%
• Oocytes 28%
• Arginine 28%
• Antidepressive Agents 27%
• Glutamic Acid 26%
• Central Nervous System 22%
• In Vitro Techniques 13%

Chemical Compounds

• Permeability 72%
• Asparagine 71%
• Substitution Reaction 57%
• Mutation 51%
• Desipramine 45%
• Antidepressant 38%
• Neurotoxicity 38%
• Plastic Property 35%
• Glutamine 33%
• Acid 31%
• Arginine 30%