Alteration of prostaglandin metabolism in alcoholic liver disease: Its association with platelet dysfunction after chronic alcohol ingestion

Masao Arai, Toshiji Kobayashi, Fumio Okuno, Yoshiaki Hirano, Kazufumi Sujita, Hiromasa Ishii, Shinzo Kato, Mari Tsugu, Hishao Takahashi, Masaharu Tsuchiya, Toshikazu Takagi, Katsuya Maruyama

Research output: Contribution to journalArticle

Abstract

Recently, hepatic microcirculation has been focused on as an important pathogenic factor in progression of alcoholic liver disease (ALD). Therefore, blood levels of several prostaglandins, which are associated with organ microcirculation, were determined in various liver diseases, including ALD. Blood thromboxane B2 (TXB2) level was significantly increased in ALD, when compared to other types of liver diseases, whereas both 6-keto prostablandin F (6-keto PGF) and prostaglandin E were not changed. These consequences resulted in the imbalance of 6-keto PGF to TXB2, which might promote platelet aggregation and blood vessel contraction. Indeed, the increase of β-thromboglobulin and platelet factor 4 in boood was observed in ALD. Furthermore, in ALD, the rate of arachidonate-induced platelet aggregation was prominently enhanced, and malondialdehyde production in platelet, which was well correlated with blood TXB2 levels, significantly increased. Thus, the present study may indicate that, in ALD, hyper-aggregability of platelet is produced, because of the derangement of prostaglandin metabolism and platelet dysfunction.

Original languageEnglish
Pages (from-to)220-226
Number of pages7
JournalNippon Shokakibyo Gakkai Zasshi
Volume86
Issue number2
DOIs
Publication statusPublished - 1989

Keywords

  • thromboxane B2
  • β-thromboglobulin

ASJC Scopus subject areas

  • Gastroenterology

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    Arai, M., Kobayashi, T., Okuno, F., Hirano, Y., Sujita, K., Ishii, H., Kato, S., Tsugu, M., Takahashi, H., Tsuchiya, M., Takagi, T., & Maruyama, K. (1989). Alteration of prostaglandin metabolism in alcoholic liver disease: Its association with platelet dysfunction after chronic alcohol ingestion. Nippon Shokakibyo Gakkai Zasshi, 86(2), 220-226. https://doi.org/10.11405/nisshoshi1964.86.220