Alterations in HbAlc resulting from the donation of autologous blood for elective surgery in patients with diabetes mellitus

Takeshi Sugimoto, Makoto Hashimoto, Ikuyo Hayakawa, Osamu Tokuno, Tomoko Ogino, Mariko Okuno, Nobuhide Hayashi, Seiji Kawano, Daisuke Sugiyama, Hironobu Minami

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background. The aim of this study was to confirm the change in haemoglobin A1c consequent to pre-operative donation of autologous blood for elective surgery in patients with diabetes mellitus. Material and methods. For enrolment in this prospective study, patients had to be scheduled for multiple autologous blood donations at different times and have a haemoglobin A1c level more than 5.8% at the first donation. The values of four factors, haemoglobin, haemoglobin A1c, glycated albumin, and glycated albumin/haemoglobin A1c ratio were determined. Changes in the values of these four factors between before and after the blood donations were calculated. Results. In all 24 patients studied, haemoglobin and haemoglobin A1c decreased as a result of the autologous blood donations. The group with a reduced glycated albumin/haemoglobin A1c ratio had short intervals between blood donations. Correlations were observed between donation interval and change in haemoglobin A1c (r=0.63, P=0.003), and between donation interval and change in the glycated albumin/haemoglobin A1c ratio (r=0.489, P=0.045). Discussion. Haemoglobin A1c levels are likely to be underestimated after autologous blood donation by patients with diabetes mellitus, so glycated albumin may be a better indicator of these patients' glycaemic control.

Original languageEnglish
JournalBlood Transfusion
Volume12
Issue numberSUPPL.1
DOIs
Publication statusPublished - 2014

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Blood Donors
Diabetes Mellitus
Hemoglobins
Glycosylated Hemoglobin A
glycosylated serum albumin
Prospective Studies

Keywords

  • Autologous blood donation
  • Glycated albumin
  • Haemoglobin A1c

ASJC Scopus subject areas

  • Hematology
  • Immunology and Allergy

Cite this

Alterations in HbAlc resulting from the donation of autologous blood for elective surgery in patients with diabetes mellitus. / Sugimoto, Takeshi; Hashimoto, Makoto; Hayakawa, Ikuyo; Tokuno, Osamu; Ogino, Tomoko; Okuno, Mariko; Hayashi, Nobuhide; Kawano, Seiji; Sugiyama, Daisuke; Minami, Hironobu.

In: Blood Transfusion, Vol. 12, No. SUPPL.1, 2014.

Research output: Contribution to journalArticle

Sugimoto, T, Hashimoto, M, Hayakawa, I, Tokuno, O, Ogino, T, Okuno, M, Hayashi, N, Kawano, S, Sugiyama, D & Minami, H 2014, 'Alterations in HbAlc resulting from the donation of autologous blood for elective surgery in patients with diabetes mellitus', Blood Transfusion, vol. 12, no. SUPPL.1. https://doi.org/10.2450/2013.0271-12
Sugimoto, Takeshi ; Hashimoto, Makoto ; Hayakawa, Ikuyo ; Tokuno, Osamu ; Ogino, Tomoko ; Okuno, Mariko ; Hayashi, Nobuhide ; Kawano, Seiji ; Sugiyama, Daisuke ; Minami, Hironobu. / Alterations in HbAlc resulting from the donation of autologous blood for elective surgery in patients with diabetes mellitus. In: Blood Transfusion. 2014 ; Vol. 12, No. SUPPL.1.
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AU - Hashimoto, Makoto

AU - Hayakawa, Ikuyo

AU - Tokuno, Osamu

AU - Ogino, Tomoko

AU - Okuno, Mariko

AU - Hayashi, Nobuhide

AU - Kawano, Seiji

AU - Sugiyama, Daisuke

AU - Minami, Hironobu

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N2 - Background. The aim of this study was to confirm the change in haemoglobin A1c consequent to pre-operative donation of autologous blood for elective surgery in patients with diabetes mellitus. Material and methods. For enrolment in this prospective study, patients had to be scheduled for multiple autologous blood donations at different times and have a haemoglobin A1c level more than 5.8% at the first donation. The values of four factors, haemoglobin, haemoglobin A1c, glycated albumin, and glycated albumin/haemoglobin A1c ratio were determined. Changes in the values of these four factors between before and after the blood donations were calculated. Results. In all 24 patients studied, haemoglobin and haemoglobin A1c decreased as a result of the autologous blood donations. The group with a reduced glycated albumin/haemoglobin A1c ratio had short intervals between blood donations. Correlations were observed between donation interval and change in haemoglobin A1c (r=0.63, P=0.003), and between donation interval and change in the glycated albumin/haemoglobin A1c ratio (r=0.489, P=0.045). Discussion. Haemoglobin A1c levels are likely to be underestimated after autologous blood donation by patients with diabetes mellitus, so glycated albumin may be a better indicator of these patients' glycaemic control.

AB - Background. The aim of this study was to confirm the change in haemoglobin A1c consequent to pre-operative donation of autologous blood for elective surgery in patients with diabetes mellitus. Material and methods. For enrolment in this prospective study, patients had to be scheduled for multiple autologous blood donations at different times and have a haemoglobin A1c level more than 5.8% at the first donation. The values of four factors, haemoglobin, haemoglobin A1c, glycated albumin, and glycated albumin/haemoglobin A1c ratio were determined. Changes in the values of these four factors between before and after the blood donations were calculated. Results. In all 24 patients studied, haemoglobin and haemoglobin A1c decreased as a result of the autologous blood donations. The group with a reduced glycated albumin/haemoglobin A1c ratio had short intervals between blood donations. Correlations were observed between donation interval and change in haemoglobin A1c (r=0.63, P=0.003), and between donation interval and change in the glycated albumin/haemoglobin A1c ratio (r=0.489, P=0.045). Discussion. Haemoglobin A1c levels are likely to be underestimated after autologous blood donation by patients with diabetes mellitus, so glycated albumin may be a better indicator of these patients' glycaemic control.

KW - Autologous blood donation

KW - Glycated albumin

KW - Haemoglobin A1c

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