Altered brain activation by a false recognition task in young abstinent patients with alcohol dependence

Yoshihide Akine, Motoichiro Kato, Taro Muramatsu, Satoshi Umeda, Masaru Mimura, Yoshiyuki Asai, Shuji Tanada, Takayuki Obata, Hiroo Ikehira, Haruo Kashima, Tetsuya Suhara

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Heavy alcohol intake induces both structural and functional changes in the central nervous system. Recent research developments converged on the idea that even in patients with alcohol dependence without apparent structural brain changes, some cognitive impairment exists, and associated functional change could be visualized by neuroimaging techniques. However, these data were from old (more than 50 years) patients using working memory and response inhibition tasks. Whether young abstinent patients show aberrant signs of brain activation is a matter of interest, specifically by the long-term memory retrieval task. Methods: Subjects were 9 young patients with alcohol dependence with long-term abstinent (8 males and 1 female) and age- and education-matched 9 healthy controls (7 males and 2 females). We used a modified false recognition task in a functional MRI study. Results: The young patients with alcohol dependence showed reduced activation in the right dorsolateral prefrontal cortex, anterior cingulate cortex (ACC), left pulvinar in the thalamus, and in the right ventral striatum, although behavioral performances and regional patterns of brain activation were similar between patients and controls. Conclusions: Long-term memory retrieval induced altered activations in prefrontal lobes, ACC, thalamus, and ventral striatum in young patients with alcohol dependence. These findings were correspondent to deficits of goal directed behavior, monitoring the erroneous responses, memory function, and drug-seeking behavior. Furthermore, these reduced activations can be considered as latent "lesions," suggesting subclinical pathology in alcoholic brains.

Original languageEnglish
Pages (from-to)1589-1597
Number of pages9
JournalAlcoholism: Clinical and Experimental Research
Volume31
Issue number9
DOIs
Publication statusPublished - 2007 Sep

Fingerprint

Alcoholism
Brain
Chemical activation
Alcohols
Data storage equipment
Long-Term Memory
Gyrus Cinguli
Neuroimaging
Neurology
Pathology
Drug-Seeking Behavior
Pulvinar
Education
Recognition (Psychology)
Prefrontal Cortex
Thalamus
Short-Term Memory
Monitoring
Central Nervous System
Magnetic Resonance Imaging

Keywords

  • Abstinent Patients With Alcohol Dependence
  • Episodic Memory
  • Functional Magnetic Resonance Imaging
  • Prefrontal Cortex
  • Thalamus

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Altered brain activation by a false recognition task in young abstinent patients with alcohol dependence. / Akine, Yoshihide; Kato, Motoichiro; Muramatsu, Taro; Umeda, Satoshi; Mimura, Masaru; Asai, Yoshiyuki; Tanada, Shuji; Obata, Takayuki; Ikehira, Hiroo; Kashima, Haruo; Suhara, Tetsuya.

In: Alcoholism: Clinical and Experimental Research, Vol. 31, No. 9, 09.2007, p. 1589-1597.

Research output: Contribution to journalArticle

Akine, Yoshihide ; Kato, Motoichiro ; Muramatsu, Taro ; Umeda, Satoshi ; Mimura, Masaru ; Asai, Yoshiyuki ; Tanada, Shuji ; Obata, Takayuki ; Ikehira, Hiroo ; Kashima, Haruo ; Suhara, Tetsuya. / Altered brain activation by a false recognition task in young abstinent patients with alcohol dependence. In: Alcoholism: Clinical and Experimental Research. 2007 ; Vol. 31, No. 9. pp. 1589-1597.
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