Altered functional connectivity associated with time discounting in chronic pain

Kenta Wakaizumi, Rami Jabakhanji, Naho Ihara, Shizuko Kosugi, Yuuri Terasawa, Hiroshi Morisaki, Masao Ogaki, Marwan N. Baliki

Research output: Contribution to journalArticle

Abstract

Chronic pain (CP) is a global problem extensively associated with an unhealthy lifestyle. Time discounting (TD), a tendency to assign less value to future gains than to present gains, is an indicator of the unhealthy behaviors. While, recent neuroimaging studies implied overlapping neuro mechanisms underlying CP and TD, little is known about the specific relationship between CP and TD in behavior or neuroscience. As such, we investigated the association of TD with behavioral measures in CP and resting-state brain functional network in both CP patients and healthy subjects. Behaviorally, TD showed a significant correlation with meaningfulness in healthy subjects, whereas TD in patients only correlated with pain intensity. We identified a specific network including medial and dorsolateral prefrontal cortex (PFC) in default mode network (DMN) associated with TD in healthy subjects that showed significant indirect mediation effect of meaningfulness on TD. In contrast, TD in patients was correlated with functional connectivity between dorsolateral PFC (DLPFC) and temporal lobe that mediated the effect of pain intensity on TD in patients. These results imply that TD is modulated by pain intensity in CP patients, and the brain function associated to TD is shifted from a medial to lateral representation within the frontal regions.

Original languageEnglish
Article number8154
JournalScientific reports
Volume9
Issue number1
DOIs
Publication statusPublished - 2019 Dec 1

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Chronic Pain
Healthy Volunteers
Prefrontal Cortex
Pain
Brain
Temporal Lobe
Neurosciences
Neuroimaging
Life Style

ASJC Scopus subject areas

  • General

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Altered functional connectivity associated with time discounting in chronic pain. / Wakaizumi, Kenta; Jabakhanji, Rami; Ihara, Naho; Kosugi, Shizuko; Terasawa, Yuuri; Morisaki, Hiroshi; Ogaki, Masao; Baliki, Marwan N.

In: Scientific reports, Vol. 9, No. 1, 8154, 01.12.2019.

Research output: Contribution to journalArticle

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AU - Terasawa, Yuuri

AU - Morisaki, Hiroshi

AU - Ogaki, Masao

AU - Baliki, Marwan N.

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