Altered perception might be a symptom of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis

Michitaka Funayama, Jin Mizushima, Taketo Takata, Akihiro Koreki, Masaru Mimura

Research output: Contribution to journalArticle

Abstract

Most patients with N-methyl-D-aspartate receptor (NMDAR) encephalitis initially present with psychiatric symptoms. Although a delayed diagnosis may lead to a poor outcome, psychiatric symptoms that could differentiate anti-NMDAR encephalitis from other psychoses have not been fully investigated. We evaluated two patients with anti-NMDAR encephalitis who were observed by psychiatrists from onset throughout the course of disease. Both patients exhibited disorientation, memory deficits, perceptual disturbances, hallucinations, and mood liability. Among those, altered perceptions were most prominent - in particular, altered time perceptions without disorganization syndrome. The information obtained for these patients may help clinicians differentiate anti-NMDAR encephalitis from other psychoses, e.g., schizophrenia.

Original languageEnglish
JournalNeurocase
DOIs
Publication statusAccepted/In press - 2019 Jan 1

Fingerprint

Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Psychiatry
Psychotic Disorders
Time Perception
Confusion
Hallucinations
Delayed Diagnosis
Memory Disorders
Encephalitis
N-Methyl-D-Aspartate Receptors
Schizophrenia

Keywords

  • Alice in Wonderland syndrome
  • altered time perceptions
  • Anti-NMDAR encephalitis
  • schizophrenia

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Altered perception might be a symptom of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. / Funayama, Michitaka; Mizushima, Jin; Takata, Taketo; Koreki, Akihiro; Mimura, Masaru.

In: Neurocase, 01.01.2019.

Research output: Contribution to journalArticle

Funayama, Michitaka ; Mizushima, Jin ; Takata, Taketo ; Koreki, Akihiro ; Mimura, Masaru. / Altered perception might be a symptom of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. In: Neurocase. 2019.
@article{2a17fea1895e426d9c3bb9797fa73229,
title = "Altered perception might be a symptom of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis",
abstract = "Most patients with N-methyl-D-aspartate receptor (NMDAR) encephalitis initially present with psychiatric symptoms. Although a delayed diagnosis may lead to a poor outcome, psychiatric symptoms that could differentiate anti-NMDAR encephalitis from other psychoses have not been fully investigated. We evaluated two patients with anti-NMDAR encephalitis who were observed by psychiatrists from onset throughout the course of disease. Both patients exhibited disorientation, memory deficits, perceptual disturbances, hallucinations, and mood liability. Among those, altered perceptions were most prominent - in particular, altered time perceptions without disorganization syndrome. The information obtained for these patients may help clinicians differentiate anti-NMDAR encephalitis from other psychoses, e.g., schizophrenia.",
keywords = "Alice in Wonderland syndrome, altered time perceptions, Anti-NMDAR encephalitis, schizophrenia",
author = "Michitaka Funayama and Jin Mizushima and Taketo Takata and Akihiro Koreki and Masaru Mimura",
year = "2019",
month = "1",
day = "1",
doi = "10.1080/13554794.2019.1573260",
language = "English",
journal = "Neurocase",
issn = "1355-4794",
publisher = "Psychology Press Ltd",

}

TY - JOUR

T1 - Altered perception might be a symptom of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis

AU - Funayama, Michitaka

AU - Mizushima, Jin

AU - Takata, Taketo

AU - Koreki, Akihiro

AU - Mimura, Masaru

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Most patients with N-methyl-D-aspartate receptor (NMDAR) encephalitis initially present with psychiatric symptoms. Although a delayed diagnosis may lead to a poor outcome, psychiatric symptoms that could differentiate anti-NMDAR encephalitis from other psychoses have not been fully investigated. We evaluated two patients with anti-NMDAR encephalitis who were observed by psychiatrists from onset throughout the course of disease. Both patients exhibited disorientation, memory deficits, perceptual disturbances, hallucinations, and mood liability. Among those, altered perceptions were most prominent - in particular, altered time perceptions without disorganization syndrome. The information obtained for these patients may help clinicians differentiate anti-NMDAR encephalitis from other psychoses, e.g., schizophrenia.

AB - Most patients with N-methyl-D-aspartate receptor (NMDAR) encephalitis initially present with psychiatric symptoms. Although a delayed diagnosis may lead to a poor outcome, psychiatric symptoms that could differentiate anti-NMDAR encephalitis from other psychoses have not been fully investigated. We evaluated two patients with anti-NMDAR encephalitis who were observed by psychiatrists from onset throughout the course of disease. Both patients exhibited disorientation, memory deficits, perceptual disturbances, hallucinations, and mood liability. Among those, altered perceptions were most prominent - in particular, altered time perceptions without disorganization syndrome. The information obtained for these patients may help clinicians differentiate anti-NMDAR encephalitis from other psychoses, e.g., schizophrenia.

KW - Alice in Wonderland syndrome

KW - altered time perceptions

KW - Anti-NMDAR encephalitis

KW - schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=85060637361&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060637361&partnerID=8YFLogxK

U2 - 10.1080/13554794.2019.1573260

DO - 10.1080/13554794.2019.1573260

M3 - Article

C2 - 30681026

AN - SCOPUS:85060637361

JO - Neurocase

JF - Neurocase

SN - 1355-4794

ER -