Altered perception might be a symptom of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis

Michitaka Funayama, Jin Mizushima, Taketo Takata, Akihiro Koreki, Masaru Mimura

Research output: Contribution to journalArticle

Abstract

Most patients with N-methyl-D-aspartate receptor (NMDAR) encephalitis initially present with psychiatric symptoms. Although a delayed diagnosis may lead to a poor outcome, psychiatric symptoms that could differentiate anti-NMDAR encephalitis from other psychoses have not been fully investigated. We evaluated two patients with anti-NMDAR encephalitis who were observed by psychiatrists from onset throughout the course of disease. Both patients exhibited disorientation, memory deficits, perceptual disturbances, hallucinations, and mood liability. Among those, altered perceptions were most prominent - in particular, altered time perceptions without disorganization syndrome. The information obtained for these patients may help clinicians differentiate anti-NMDAR encephalitis from other psychoses, e.g., schizophrenia.

Original languageEnglish
JournalNeurocase
DOIs
Publication statusAccepted/In press - 2019 Jan 1

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Keywords

  • Alice in Wonderland syndrome
  • altered time perceptions
  • Anti-NMDAR encephalitis
  • schizophrenia

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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