Alu elements as an aid in deciphering genome rearrangements

Yoshimi Toda, Masaru Tomita

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Genomic rearrangements result in genomic duplications that lead to the generation of more complex genomes. Some attempts have been made to trace duplication histories of different loci using Alu elements because of their large population in primate genomes. In this short report, using the human growth hormone locus as an example, we demonstrate the usefulness of Alu repetitive elements in computer sequence analyses when tracing duplication histories. Information on subfamily classification, direction, arrangements, Poly(A) tails and direct repeats can aid our understanding of genome rearrangements.

Original languageEnglish
Pages (from-to)173-176
Number of pages4
JournalGene
Volume205
Issue number1-2
DOIs
Publication statusPublished - 1997 Dec 31

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Keywords

  • Computer
  • Direct repeat
  • Evolutionary distance
  • Poly(A) tail
  • Sequence evolution

ASJC Scopus subject areas

  • Genetics

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