Alveolar architecture of clear cell renal carcinomas (≤5.0 cm) show high attenuation on dynamic CT scanning

Hiroyuki Fujimoto, Fumihiko Wakao, Noriyuki Moriyama, Kenichi Tobisu, Michiie Sakamoto, Tadao Kakizoe

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: To establish the correlation between tumor appearance on CT and tumor histology in renal cell carcinomas. Methods: The density and attenuation patterns of 96 renal cell carcinomas, each ≤5 cm in greatest diameter, were studied by non-enhanced CT and early and late after bolus injection of contrast medium using dynamic CT. The density and attenuation patterns and pathological maps of each tumor were individually correlated. Results: High attenuated areas were present in 72 of the 96 tumors on early enhanced dynamic CT scanning. All 72 high attenuated areas were of the clear cell renal cell carcinoma and had alveolar architecture. The remaining 24 tumors that did not demonstrate high attenuated foci on early enhanced scanning included three clear cell, nine granular cell, six papillary, five chromophobe and one collecting duct type. With respect to tumor architecture, all clear cell tumors of alveolar architecture demonstrated high attenuation on early enhanced scanning. Conclusion: Clear cell renal cell carcinomas of alveolar architecture show high attenuation on early enhanced dynamic CT scanning. A larger number of patients are indispensable to obtaining clear results. However, these findings seem to be an important clue to the diagnosis of renal cell carcinomas as having an alveolar structure.

Original languageEnglish
Pages (from-to)198-203
Number of pages6
JournalJapanese Journal of Clinical Oncology
Volume29
Issue number4
Publication statusPublished - 1999 Apr
Externally publishedYes

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Renal Cell Carcinoma
Neoplasms
Naphazoline
Alveolar Epithelial Cells
Contrast Media
Histology
Injections

Keywords

  • Attenuation
  • Computed tomography
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Oncology

Cite this

Alveolar architecture of clear cell renal carcinomas (≤5.0 cm) show high attenuation on dynamic CT scanning. / Fujimoto, Hiroyuki; Wakao, Fumihiko; Moriyama, Noriyuki; Tobisu, Kenichi; Sakamoto, Michiie; Kakizoe, Tadao.

In: Japanese Journal of Clinical Oncology, Vol. 29, No. 4, 04.1999, p. 198-203.

Research output: Contribution to journalArticle

Fujimoto, Hiroyuki ; Wakao, Fumihiko ; Moriyama, Noriyuki ; Tobisu, Kenichi ; Sakamoto, Michiie ; Kakizoe, Tadao. / Alveolar architecture of clear cell renal carcinomas (≤5.0 cm) show high attenuation on dynamic CT scanning. In: Japanese Journal of Clinical Oncology. 1999 ; Vol. 29, No. 4. pp. 198-203.
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AU - Fujimoto, Hiroyuki

AU - Wakao, Fumihiko

AU - Moriyama, Noriyuki

AU - Tobisu, Kenichi

AU - Sakamoto, Michiie

AU - Kakizoe, Tadao

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AB - Background: To establish the correlation between tumor appearance on CT and tumor histology in renal cell carcinomas. Methods: The density and attenuation patterns of 96 renal cell carcinomas, each ≤5 cm in greatest diameter, were studied by non-enhanced CT and early and late after bolus injection of contrast medium using dynamic CT. The density and attenuation patterns and pathological maps of each tumor were individually correlated. Results: High attenuated areas were present in 72 of the 96 tumors on early enhanced dynamic CT scanning. All 72 high attenuated areas were of the clear cell renal cell carcinoma and had alveolar architecture. The remaining 24 tumors that did not demonstrate high attenuated foci on early enhanced scanning included three clear cell, nine granular cell, six papillary, five chromophobe and one collecting duct type. With respect to tumor architecture, all clear cell tumors of alveolar architecture demonstrated high attenuation on early enhanced scanning. Conclusion: Clear cell renal cell carcinomas of alveolar architecture show high attenuation on early enhanced dynamic CT scanning. A larger number of patients are indispensable to obtaining clear results. However, these findings seem to be an important clue to the diagnosis of renal cell carcinomas as having an alveolar structure.

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