Ambient fine and coarse particles in Japan affect nasal and bronchial epithelial cells differently and elicit varying immune response

Toshinori Onishi, Akiko Honda, Michitaka Tanaka, Pratiti H. Chowdhury, Hitoshi Okano, Tomoaki Okuda, Daiki Shishido, Yoshihiro Terui, Shuichi Hasegawa, Takayuki Kameda, Susumu Tohno, Masahiko Hayashi, Chiharu Nishita-Hara, Keiichiro Hara, Kozo Inoue, Makoto Yasuda, Shigeru Hirano, Hirohisa Takano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Ambient particulate matter (PM) epidemiologically exacerbates respiratory and immune health, including allergic rhinitis (AR) and bronchial asthma (BA). Although fine and coarse particles can affect respiratory tract, the differences in their effects on the upper and lower respiratory tract and immune system, their underlying mechanism, and the components responsible for the adverse health effects have not been yet completely elucidated. In this study, ambient fine and coarse particles were collected at three different locations in Japan by cyclone technique. Both particles collected at all locations decreased the viability of nasal epithelial cells and antigen presenting cells (APCs), increased the production of IL-6, IL-8, and IL-1β from bronchial epithelial cells and APCs, and induced expression of dendritic and epithelial cell (DEC) 205 on APCs. Differences in inflammatory responses, but not in cytotoxicity, were shown between both particles, and among three locations. Some components such as Ti, Co, Zn, Pb, As, OC (organic carbon) and EC (elemental carbon) showed significant correlations to inflammatory responses or cytotoxicity. These results suggest that ambient fine and coarse particles differently affect nasal and bronchial epithelial cells and immune response, which may depend on particles size diameter, chemical composition and source related particles types. We showed for the first time in the world that ambient fine and coarse particles collected from Japan by the new technique using cyclone have different effects on the epithelium cells of the upper and lower respiratory tract and elicit varying immune response, which may depend on particles size diameter, chemical composition and source related particles types.

Original languageEnglish
Pages (from-to)1693-1701
Number of pages9
JournalEnvironmental Pollution
Volume242
DOIs
Publication statusPublished - 2018 Nov 1

Fingerprint

Nose
Respiratory System
Japan
Antigen-Presenting Cells
Epithelial Cells
Cyclonic Storms
Cytotoxicity
Particle Size
Carbon
Particle size
Health
Respiratory system
Particulate Matter
Immune system
Organic carbon
Chemical analysis
Interleukin-8
Interleukin-1
Dendritic Cells
Immune System

Keywords

  • Ambient particulate matter
  • Cyclone technique
  • Immune cells
  • Inflammatory responses
  • Respiratory cells

ASJC Scopus subject areas

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Ambient fine and coarse particles in Japan affect nasal and bronchial epithelial cells differently and elicit varying immune response. / Onishi, Toshinori; Honda, Akiko; Tanaka, Michitaka; Chowdhury, Pratiti H.; Okano, Hitoshi; Okuda, Tomoaki; Shishido, Daiki; Terui, Yoshihiro; Hasegawa, Shuichi; Kameda, Takayuki; Tohno, Susumu; Hayashi, Masahiko; Nishita-Hara, Chiharu; Hara, Keiichiro; Inoue, Kozo; Yasuda, Makoto; Hirano, Shigeru; Takano, Hirohisa.

In: Environmental Pollution, Vol. 242, 01.11.2018, p. 1693-1701.

Research output: Contribution to journalArticle

Onishi, T, Honda, A, Tanaka, M, Chowdhury, PH, Okano, H, Okuda, T, Shishido, D, Terui, Y, Hasegawa, S, Kameda, T, Tohno, S, Hayashi, M, Nishita-Hara, C, Hara, K, Inoue, K, Yasuda, M, Hirano, S & Takano, H 2018, 'Ambient fine and coarse particles in Japan affect nasal and bronchial epithelial cells differently and elicit varying immune response', Environmental Pollution, vol. 242, pp. 1693-1701. https://doi.org/10.1016/j.envpol.2018.07.103
Onishi, Toshinori ; Honda, Akiko ; Tanaka, Michitaka ; Chowdhury, Pratiti H. ; Okano, Hitoshi ; Okuda, Tomoaki ; Shishido, Daiki ; Terui, Yoshihiro ; Hasegawa, Shuichi ; Kameda, Takayuki ; Tohno, Susumu ; Hayashi, Masahiko ; Nishita-Hara, Chiharu ; Hara, Keiichiro ; Inoue, Kozo ; Yasuda, Makoto ; Hirano, Shigeru ; Takano, Hirohisa. / Ambient fine and coarse particles in Japan affect nasal and bronchial epithelial cells differently and elicit varying immune response. In: Environmental Pollution. 2018 ; Vol. 242. pp. 1693-1701.
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AU - Onishi, Toshinori

AU - Honda, Akiko

AU - Tanaka, Michitaka

AU - Chowdhury, Pratiti H.

AU - Okano, Hitoshi

AU - Okuda, Tomoaki

AU - Shishido, Daiki

AU - Terui, Yoshihiro

AU - Hasegawa, Shuichi

AU - Kameda, Takayuki

AU - Tohno, Susumu

AU - Hayashi, Masahiko

AU - Nishita-Hara, Chiharu

AU - Hara, Keiichiro

AU - Inoue, Kozo

AU - Yasuda, Makoto

AU - Hirano, Shigeru

AU - Takano, Hirohisa

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N2 - Ambient particulate matter (PM) epidemiologically exacerbates respiratory and immune health, including allergic rhinitis (AR) and bronchial asthma (BA). Although fine and coarse particles can affect respiratory tract, the differences in their effects on the upper and lower respiratory tract and immune system, their underlying mechanism, and the components responsible for the adverse health effects have not been yet completely elucidated. In this study, ambient fine and coarse particles were collected at three different locations in Japan by cyclone technique. Both particles collected at all locations decreased the viability of nasal epithelial cells and antigen presenting cells (APCs), increased the production of IL-6, IL-8, and IL-1β from bronchial epithelial cells and APCs, and induced expression of dendritic and epithelial cell (DEC) 205 on APCs. Differences in inflammatory responses, but not in cytotoxicity, were shown between both particles, and among three locations. Some components such as Ti, Co, Zn, Pb, As, OC (organic carbon) and EC (elemental carbon) showed significant correlations to inflammatory responses or cytotoxicity. These results suggest that ambient fine and coarse particles differently affect nasal and bronchial epithelial cells and immune response, which may depend on particles size diameter, chemical composition and source related particles types. We showed for the first time in the world that ambient fine and coarse particles collected from Japan by the new technique using cyclone have different effects on the epithelium cells of the upper and lower respiratory tract and elicit varying immune response, which may depend on particles size diameter, chemical composition and source related particles types.

AB - Ambient particulate matter (PM) epidemiologically exacerbates respiratory and immune health, including allergic rhinitis (AR) and bronchial asthma (BA). Although fine and coarse particles can affect respiratory tract, the differences in their effects on the upper and lower respiratory tract and immune system, their underlying mechanism, and the components responsible for the adverse health effects have not been yet completely elucidated. In this study, ambient fine and coarse particles were collected at three different locations in Japan by cyclone technique. Both particles collected at all locations decreased the viability of nasal epithelial cells and antigen presenting cells (APCs), increased the production of IL-6, IL-8, and IL-1β from bronchial epithelial cells and APCs, and induced expression of dendritic and epithelial cell (DEC) 205 on APCs. Differences in inflammatory responses, but not in cytotoxicity, were shown between both particles, and among three locations. Some components such as Ti, Co, Zn, Pb, As, OC (organic carbon) and EC (elemental carbon) showed significant correlations to inflammatory responses or cytotoxicity. These results suggest that ambient fine and coarse particles differently affect nasal and bronchial epithelial cells and immune response, which may depend on particles size diameter, chemical composition and source related particles types. We showed for the first time in the world that ambient fine and coarse particles collected from Japan by the new technique using cyclone have different effects on the epithelium cells of the upper and lower respiratory tract and elicit varying immune response, which may depend on particles size diameter, chemical composition and source related particles types.

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KW - Respiratory cells

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