Amidation reaction of carboxylic acid with formamide derivative using SO3•pyridine

Shota Kawano, Kodai Saito, Tohru Yamada

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2 Citations (Scopus)


The amidation reaction of carboxylic acid derivatives was developed using sulfur trioxide pyridine complex (SO3•py) as a commercially available and easily handled oxidant. This method could be applied to the reaction of various aromatic and aliphatic carboxylic acids, including optically active ones, with formamide derivatives to afford the corresponding amides in good to high yields.

Original languageEnglish
Pages (from-to)584-586
Number of pages3
JournalChemistry Letters
Issue number4
Publication statusPublished - 2018 Jan 1



  • Amidation
  • Metal-free synthesis
  • Sulfur oxide

ASJC Scopus subject areas

  • Chemistry(all)

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