Amidation reaction of carboxylic acid with formamide derivative using SO3•pyridine

Shota Kawano, Kodai Saito, Tohru Yamada

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The amidation reaction of carboxylic acid derivatives was developed using sulfur trioxide pyridine complex (SO3•py) as a commercially available and easily handled oxidant. This method could be applied to the reaction of various aromatic and aliphatic carboxylic acids, including optically active ones, with formamide derivatives to afford the corresponding amides in good to high yields.

Original languageEnglish
Pages (from-to)584-586
Number of pages3
JournalChemistry Letters
Volume47
Issue number4
DOIs
Publication statusPublished - 2018 Jan 1

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Carboxylic Acids
Derivatives
Oxidants
Amides
formamide
pyridine
sulfur trioxide

Keywords

  • Amidation
  • Metal-free synthesis
  • Sulfur oxide

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Amidation reaction of carboxylic acid with formamide derivative using SO3•pyridine. / Kawano, Shota; Saito, Kodai; Yamada, Tohru.

In: Chemistry Letters, Vol. 47, No. 4, 01.01.2018, p. 584-586.

Research output: Contribution to journalArticle

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