Amiloride blocks salt taste transduction of the glossopharyngeal nerve in metamorphosed salamanders

Takatoshi Nagai, Daisuke Nii, Hiro Aki Takeuchi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Studies in the last two decades have shown that amiloride-sensitive Na+ channels play a role in NaCl transduction in rat taste receptors. However, this role is not readily generalized for salt taste transduction in vertebrates, because functional expression of these channels varies across species and also in development in a species. Glossopharyngeal nerve responses to sodium and potassium salts were recorded in larval and metamorphosed salamanders and compared before and after the oral floor was exposed to amiloride, a blocker of Na+ channels known to be responsible for epithelial ion transport. Pre-exposure to amiloride (100 μM) did not affect salt taste responses in both axolotls (Ambystoma mexicanum) and larval Ezo salamanders (Hynobius retardatus). In contrast, in metamorphosed Ezo salamanders the nerve responses to NaCl were significantly reduced by amiloride. In amphibians amiloride-sensitive components in salt taste transduction seem to develop during metamorphosis.

Original languageEnglish
Pages (from-to)965-969
Number of pages5
JournalChemical Senses
Volume26
Issue number8
Publication statusPublished - 2001

Fingerprint

Glossopharyngeal Nerve
Urodela
Amiloride
salamanders and newts
nerve tissue
Salts
salts
Ambystoma mexicanum
ion transport
Mouth Floor
metamorphosis
Ion Transport
amphibians
Amphibians
mouth
vertebrates
potassium
sodium
Vertebrates
Potassium

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Neuroscience(all)
  • Physiology
  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Amiloride blocks salt taste transduction of the glossopharyngeal nerve in metamorphosed salamanders. / Nagai, Takatoshi; Nii, Daisuke; Takeuchi, Hiro Aki.

In: Chemical Senses, Vol. 26, No. 8, 2001, p. 965-969.

Research output: Contribution to journalArticle

Nagai, Takatoshi ; Nii, Daisuke ; Takeuchi, Hiro Aki. / Amiloride blocks salt taste transduction of the glossopharyngeal nerve in metamorphosed salamanders. In: Chemical Senses. 2001 ; Vol. 26, No. 8. pp. 965-969.
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