Amniotic membrane hybridized PVA artificial cornea

Hisatoshi Kobayashi, Tetsushi Taguchi, Masabumi Kato, Shigeto Shimmura, Hideyuki Miyashita, Kazuo Tsubota, Junzo Tanaka

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Collagen immobilized PVA Hydrogel has been developed as a artificial corneal materials and demonstrated the formation of the corneal epithelium layer on the surface in rabbit model. In this study, to improve the in vivo stability, amniotic membrane hybridized PVA artificial cornea is newly synthesized and evaluated the corneal epithelium formation on the surface using rabbit model. The amniotic membrane hybridized PVA was successfully prepared and it was stable in PBS at least two months. Corneal epithelium was stratification on the amniotic membrane hybridized PVA in in vitro. The amniotic membrane hybridized PVA was completely epithelialized within two weeks and the hybrid artificial corne a kept the transparency. The long-term stability test will be required.

Original languageEnglish
Title of host publicationPolymer Preprints, Japan
Number of pages1
Publication statusPublished - 2005
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: 2005 Sep 202005 Sep 22


Other54th SPSJ Symposium on Macromolecules



  • Amniotic membrane
  • Artificial cornea
  • Epithelialization
  • Hybrid
  • PVA hydrogel

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Kobayashi, H., Taguchi, T., Kato, M., Shimmura, S., Miyashita, H., Tsubota, K., & Tanaka, J. (2005). Amniotic membrane hybridized PVA artificial cornea. In Polymer Preprints, Japan (2 ed., Vol. 54, pp. 5004)