Amniotic membrane hybridized PVA artificial cornea

Hisatoshi Kobayashi; Tetsushi Taguchi; Masabumi Kato; Shigeto Shimmura; Hideyuki Miyashita; Kazuo Tsubota; Junzo Tanaka

Amniotic membrane hybridized PVA artificial cornea

Hisatoshi Kobayashi, Tetsushi Taguchi, Masabumi Kato, Shigeto Shimmura, Hideyuki Miyashita, Kazuo Tsubota, Junzo Tanaka

Department of Ophthalmology

Research output: Contribution to conference › Paper › peer-review

Abstract

Collagen immobilized PVA Hydrogel has been developed as a artificial corneal materials and demonstrated the formation of the corneal epithelium layer on the surface in rabbit model. In this study, to improve the in vivo stability, amniotic membrane hybridized PVA artificial cornea is newly synthesized and evaluated the corneal epithelium formation on the surface using rabbit model. The amniotic membrane hybridized PVA was successfully prepared and it was stable in PBS at least two months. Corneal epithelium was stratification on the amniotic membrane hybridized PVA in in vitro. The amniotic membrane hybridized PVA was completely epithelialized within two weeks and the hybrid artificial corne a kept the transparency. The long-term stability test will be required.

Original language	English
Number of pages	1
Publication status	Published - 2005 Dec 1
Event	54th SPSJ Symposium on Macromolecules - Yamagata, Japan Duration: 2005 Sep 20 → 2005 Sep 22

Other

Other	54th SPSJ Symposium on Macromolecules
Country	Japan
City	Yamagata
Period	05/9/20 → 05/9/22

Keywords

Amniotic membrane
Artificial cornea
Epithelialization
Hybrid
PVA hydrogel

ASJC Scopus subject areas

Engineering(all)

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Cite this

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title = "Amniotic membrane hybridized PVA artificial cornea",

abstract = "Collagen immobilized PVA Hydrogel has been developed as a artificial corneal materials and demonstrated the formation of the corneal epithelium layer on the surface in rabbit model. In this study, to improve the in vivo stability, amniotic membrane hybridized PVA artificial cornea is newly synthesized and evaluated the corneal epithelium formation on the surface using rabbit model. The amniotic membrane hybridized PVA was successfully prepared and it was stable in PBS at least two months. Corneal epithelium was stratification on the amniotic membrane hybridized PVA in in vitro. The amniotic membrane hybridized PVA was completely epithelialized within two weeks and the hybrid artificial corne a kept the transparency. The long-term stability test will be required.",

keywords = "Amniotic membrane, Artificial cornea, Epithelialization, Hybrid, PVA hydrogel",

author = "Hisatoshi Kobayashi and Tetsushi Taguchi and Masabumi Kato and Shigeto Shimmura and Hideyuki Miyashita and Kazuo Tsubota and Junzo Tanaka",

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T1 - Amniotic membrane hybridized PVA artificial cornea

AU - Kobayashi, Hisatoshi

AU - Taguchi, Tetsushi

AU - Kato, Masabumi

AU - Shimmura, Shigeto

AU - Miyashita, Hideyuki

AU - Tsubota, Kazuo

AU - Tanaka, Junzo

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Collagen immobilized PVA Hydrogel has been developed as a artificial corneal materials and demonstrated the formation of the corneal epithelium layer on the surface in rabbit model. In this study, to improve the in vivo stability, amniotic membrane hybridized PVA artificial cornea is newly synthesized and evaluated the corneal epithelium formation on the surface using rabbit model. The amniotic membrane hybridized PVA was successfully prepared and it was stable in PBS at least two months. Corneal epithelium was stratification on the amniotic membrane hybridized PVA in in vitro. The amniotic membrane hybridized PVA was completely epithelialized within two weeks and the hybrid artificial corne a kept the transparency. The long-term stability test will be required.

AB - Collagen immobilized PVA Hydrogel has been developed as a artificial corneal materials and demonstrated the formation of the corneal epithelium layer on the surface in rabbit model. In this study, to improve the in vivo stability, amniotic membrane hybridized PVA artificial cornea is newly synthesized and evaluated the corneal epithelium formation on the surface using rabbit model. The amniotic membrane hybridized PVA was successfully prepared and it was stable in PBS at least two months. Corneal epithelium was stratification on the amniotic membrane hybridized PVA in in vitro. The amniotic membrane hybridized PVA was completely epithelialized within two weeks and the hybrid artificial corne a kept the transparency. The long-term stability test will be required.

KW - Amniotic membrane

KW - Artificial cornea

KW - Epithelialization

KW - Hybrid

KW - PVA hydrogel

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