Abstract
Collagen immobilized PVA Hydrogel has been developed as a artificial corneal materials and demonstrated the formation of the corneal epithelium layer on the surface in rabbit model. In this study, to improve the in vivo stability, amniotic membrane hybridized PVA artificial cornea is newly synthesized and evaluated the corneal epithelium formation on the surface using rabbit model. The amniotic membrane hybridized PVA was successfully prepared and it was stable in PBS at least two months. Corneal epithelium was stratification on the amniotic membrane hybridized PVA in in vitro. The amniotic membrane hybridized PVA was completely epithelialized within two weeks and the hybrid artificial corne a kept the transparency. The long-term stability test will be required.
| Original language | English |
|---|---|
| Title of host publication | Polymer Preprints, Japan |
| Pages | 5004 |
| Number of pages | 1 |
| Volume | 54 |
| Edition | 2 |
| Publication status | Published - 2005 |
| Event | 54th SPSJ Symposium on Macromolecules - Yamagata, Japan Duration: 2005 Sep 20 → 2005 Sep 22 |
Other
| Other | 54th SPSJ Symposium on Macromolecules |
|---|---|
| Country | Japan |
| City | Yamagata |
| Period | 05/9/20 → 05/9/22 |
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Keywords
- Amniotic membrane
- Artificial cornea
- Epithelialization
- Hybrid
- PVA hydrogel
ASJC Scopus subject areas
- Engineering(all)
Cite this
Amniotic membrane hybridized PVA artificial cornea. / Kobayashi, Hisatoshi; Taguchi, Tetsushi; Kato, Masabumi; Shimmura, Shigeto; Miyashita, Hideyuki; Tsubota, Kazuo; Tanaka, Junzo.
Polymer Preprints, Japan. Vol. 54 2. ed. 2005. p. 5004.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Amniotic membrane hybridized PVA artificial cornea
AU - Kobayashi, Hisatoshi
AU - Taguchi, Tetsushi
AU - Kato, Masabumi
AU - Shimmura, Shigeto
AU - Miyashita, Hideyuki
AU - Tsubota, Kazuo
AU - Tanaka, Junzo
PY - 2005
Y1 - 2005
N2 - Collagen immobilized PVA Hydrogel has been developed as a artificial corneal materials and demonstrated the formation of the corneal epithelium layer on the surface in rabbit model. In this study, to improve the in vivo stability, amniotic membrane hybridized PVA artificial cornea is newly synthesized and evaluated the corneal epithelium formation on the surface using rabbit model. The amniotic membrane hybridized PVA was successfully prepared and it was stable in PBS at least two months. Corneal epithelium was stratification on the amniotic membrane hybridized PVA in in vitro. The amniotic membrane hybridized PVA was completely epithelialized within two weeks and the hybrid artificial corne a kept the transparency. The long-term stability test will be required.
AB - Collagen immobilized PVA Hydrogel has been developed as a artificial corneal materials and demonstrated the formation of the corneal epithelium layer on the surface in rabbit model. In this study, to improve the in vivo stability, amniotic membrane hybridized PVA artificial cornea is newly synthesized and evaluated the corneal epithelium formation on the surface using rabbit model. The amniotic membrane hybridized PVA was successfully prepared and it was stable in PBS at least two months. Corneal epithelium was stratification on the amniotic membrane hybridized PVA in in vitro. The amniotic membrane hybridized PVA was completely epithelialized within two weeks and the hybrid artificial corne a kept the transparency. The long-term stability test will be required.
KW - Amniotic membrane
KW - Artificial cornea
KW - Epithelialization
KW - Hybrid
KW - PVA hydrogel
UR - http://www.scopus.com/inward/record.url?scp=33645644781&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645644781&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:33645644781
VL - 54
SP - 5004
BT - Polymer Preprints, Japan
ER -