TY - GEN
T1 - Amyloid-β Clearance and its Evaluation by Auditory Stimulation in a Mouse Model of Alzheimer's Disease
AU - Ogawa, Maika
AU - Mitsukura, Yasue
AU - Abe, Yoichiro
AU - Yasui, Masato
N1 - Publisher Copyright:
© 2022 IEEE.
PY - 2022
Y1 - 2022
N2 - The purpose of this study was to quantify the clearance of amyloid-β (Aβ) protein by auditory stimulation in a mouse model of Alzheimer's disease (AD). Accumulation of Aβ is thought to be one of the causes of AD. It has been confirmed that Aβ in 5XFAD mice, a mouse model of AD, is reduced by auditory stimulation at a period of 40 Hz, in which sounds are switched on and off 40 times per second. A previous study showed that auditory stimulation of 1-8 msec duration may be particularly effective for Aβ clearance. However, quantitative evaluation of Aβ has not yet been conducted. Therefore, in this study, we quantitatively evaluated the effect of auditory stimulation on Aβ clearance by analyzing the amount of Aβ. As a result, auditory stimulation using a sound with a period of 40 Hz, a pitch of 10 kHz, and a duration of 3 msec reduced the magnitude of Aβ.
AB - The purpose of this study was to quantify the clearance of amyloid-β (Aβ) protein by auditory stimulation in a mouse model of Alzheimer's disease (AD). Accumulation of Aβ is thought to be one of the causes of AD. It has been confirmed that Aβ in 5XFAD mice, a mouse model of AD, is reduced by auditory stimulation at a period of 40 Hz, in which sounds are switched on and off 40 times per second. A previous study showed that auditory stimulation of 1-8 msec duration may be particularly effective for Aβ clearance. However, quantitative evaluation of Aβ has not yet been conducted. Therefore, in this study, we quantitatively evaluated the effect of auditory stimulation on Aβ clearance by analyzing the amount of Aβ. As a result, auditory stimulation using a sound with a period of 40 Hz, a pitch of 10 kHz, and a duration of 3 msec reduced the magnitude of Aβ.
KW - Alzheimer's disease
KW - Amyloid-beta
KW - Audio-cortex
KW - Mouse model
KW - Oscillations
UR - http://www.scopus.com/inward/record.url?scp=85143893457&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85143893457&partnerID=8YFLogxK
U2 - 10.1109/IECON49645.2022.9968672
DO - 10.1109/IECON49645.2022.9968672
M3 - Conference contribution
AN - SCOPUS:85143893457
T3 - IECON Proceedings (Industrial Electronics Conference)
BT - IECON 2022 - 48th Annual Conference of the IEEE Industrial Electronics Society
PB - IEEE Computer Society
T2 - 48th Annual Conference of the IEEE Industrial Electronics Society, IECON 2022
Y2 - 17 October 2022 through 20 October 2022
ER -