An access to the 13-membered cyclophane substructure in GKK1032AS: An intramolecular 1,4-addition approach

Satoka Nagai, Yuka Yamagishi, Yuta Shimizu, Kenichi Takao, Kin Ichi Tadano

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The construction of the 13-membered para-cyclophane substructure in GKK1032As, a member of novel pyrrolidinone-containing bioactive natural products, has been explored. An efficient approach for this synthetically formidable object was found, which relied on an intramolecular 1,4-addition between a nitromethylene group and a vinyl ketone moiety both incorporated as side chains into the 6/5/6-tricyclic (the A/B/C-ring system) of the GKK1032s.

Original languageEnglish
Pages (from-to)819-826
Number of pages8
JournalHeterocycles
Volume90
Issue number2
DOIs
Publication statusPublished - 2015

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Pyrrolidinones
Biological Products
Ketones

ASJC Scopus subject areas

  • Analytical Chemistry
  • Organic Chemistry
  • Pharmacology

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An access to the 13-membered cyclophane substructure in GKK1032AS : An intramolecular 1,4-addition approach. / Nagai, Satoka; Yamagishi, Yuka; Shimizu, Yuta; Takao, Kenichi; Tadano, Kin Ichi.

In: Heterocycles, Vol. 90, No. 2, 2015, p. 819-826.

Research output: Contribution to journalArticle

Nagai, Satoka ; Yamagishi, Yuka ; Shimizu, Yuta ; Takao, Kenichi ; Tadano, Kin Ichi. / An access to the 13-membered cyclophane substructure in GKK1032AS : An intramolecular 1,4-addition approach. In: Heterocycles. 2015 ; Vol. 90, No. 2. pp. 819-826.
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