An access to the 13-membered cyclophane substructure in GKK1032AS: An intramolecular 1,4-addition approach

Satoka Nagai, Yuka Yamagishi, Yuta Shimizu, Ken Ichi Takao, Kin Ichi Tadano

Research output: Contribution to journalArticle

4 Citations (Scopus)


The construction of the 13-membered para-cyclophane substructure in GKK1032As, a member of novel pyrrolidinone-containing bioactive natural products, has been explored. An efficient approach for this synthetically formidable object was found, which relied on an intramolecular 1,4-addition between a nitromethylene group and a vinyl ketone moiety both incorporated as side chains into the 6/5/6-tricyclic (the A/B/C-ring system) of the GKK1032s.

Original languageEnglish
Pages (from-to)819-826
Number of pages8
Issue number2
Publication statusPublished - 2015


ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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