An acidic polysaccharide having activity on the reticuloendothelial system from the root of Astragalus mongholicus

N. Shimizu, M. Tomoda, M. Kanari, Ryoko Gonda

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

An acidic polysaccharide, designated as AMon-S, was isolated from the roots of Astragalus mongholicus BUNGE. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 7.6 x 104. It showed significant reticuloendothelial system-potentiating activityin a carbon clearance test. It is composed of L-arabinose: D-galactose: D-galacturonic acid: D-glucuronic acid in the molar ratio of 18:18:1:1, in addition to small amounts of O-acetyl groups and peptide moiety. A part of the hexuronic acid residues exist as the methyl esters. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies enabled elucidation of its structural features and revealed mainly α-arabino-β-3,6-galactan type structural units.

Original languageEnglish
Pages (from-to)2969-2972
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume39
Issue number11
Publication statusPublished - 1991

Fingerprint

Mononuclear Phagocyte System
Polysaccharides
Hexuronic Acids
Carbon
Galactans
Glucuronic Acid
Arabinose
Methylation
Molecular mass
Chromatography
Electrophoresis
Galactose
Gel Chromatography
Esters
Magnetic Resonance Spectroscopy
Gels
Nuclear magnetic resonance
Oxidation
Peptides
metaperiodate

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

An acidic polysaccharide having activity on the reticuloendothelial system from the root of Astragalus mongholicus. / Shimizu, N.; Tomoda, M.; Kanari, M.; Gonda, Ryoko.

In: Chemical and Pharmaceutical Bulletin, Vol. 39, No. 11, 1991, p. 2969-2972.

Research output: Contribution to journalArticle

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