An Acidic Polysaccharide Having Activity on the Reticuloendothelial System from the Bark of Eucommia ulmoides

Ryoko Gonda; Masashi Tomoda; Noriko Shimizu; Mieko Kanari

doi:10.1248/cpb.38.1966

An Acidic Polysaccharide Having Activity on the Reticuloendothelial System from the Bark of Eucommia ulmoides

Ryoko Gonda, Masashi Tomoda, Noriko Shimizu, Mieko Kanari

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

An acidic polysaccharide, named eucomman A, was isolated from the dried bark of Eucommia ulmoides oliv. It was homogeneous on electrophoresis and gel chromatography, and showed significant reticuloendothelial system-potentiating activity in a carbon clearance test. It is composed of L-arabinose: D-galactose: D-glucose: l-rhamnose: D-galacturonic acid in the molar ratio of 8:6:4:5:8 in addition to small amounts of peptide moiety. Its molecular mass was estimated to be 6.0 x 104. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies enabled elucidation of its structural features.

Original language	English
Pages (from-to)	1966-1969
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	38
Issue number	7
DOIs	https://doi.org/10.1248/cpb.38.1966
Publication status	Published - 1990

Keywords

Eucommia ulmoides
acidic polysaccharide
bark
eucomman A
immunological activity
methylation analysis
polysaccharide structure
reticuloendothelial system

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.38.1966

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abstract = "An acidic polysaccharide, named eucomman A, was isolated from the dried bark of Eucommia ulmoides oliv. It was homogeneous on electrophoresis and gel chromatography, and showed significant reticuloendothelial system-potentiating activity in a carbon clearance test. It is composed of L-arabinose: D-galactose: D-glucose: l-rhamnose: D-galacturonic acid in the molar ratio of 8:6:4:5:8 in addition to small amounts of peptide moiety. Its molecular mass was estimated to be 6.0 x 104. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies enabled elucidation of its structural features.",

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AU - Gonda, Ryoko

AU - Tomoda, Masashi

AU - Shimizu, Noriko

AU - Kanari, Mieko

PY - 1990

Y1 - 1990

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AB - An acidic polysaccharide, named eucomman A, was isolated from the dried bark of Eucommia ulmoides oliv. It was homogeneous on electrophoresis and gel chromatography, and showed significant reticuloendothelial system-potentiating activity in a carbon clearance test. It is composed of L-arabinose: D-galactose: D-glucose: l-rhamnose: D-galacturonic acid in the molar ratio of 8:6:4:5:8 in addition to small amounts of peptide moiety. Its molecular mass was estimated to be 6.0 x 104. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies enabled elucidation of its structural features.

KW - Eucommia ulmoides

KW - acidic polysaccharide

KW - bark

KW - eucomman A

KW - immunological activity

KW - methylation analysis

KW - polysaccharide structure

KW - reticuloendothelial system

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An Acidic Polysaccharide Having Activity on the Reticuloendothelial System from the Bark of Eucommia ulmoides

Abstract

Keywords

ASJC Scopus subject areas

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