An Acidic Polysaccharide Having Activity on the Reticuloendothelial System from the Bark of Eucommia ulmoides

Ryoko Gonda, Masashi Tomoda, Noriko Shimizu, Mieko Kanari

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Abstract

An acidic polysaccharide, named eucomman A, was isolated from the dried bark of Eucommia ulmoides oliv. It was homogeneous on electrophoresis and gel chromatography, and showed significant reticuloendothelial system-potentiating activity in a carbon clearance test. It is composed of L-arabinose: D-galactose: D-glucose: l-rhamnose: D-galacturonic acid in the molar ratio of 8:6:4:5:8 in addition to small amounts of peptide moiety. Its molecular mass was estimated to be 6.0 x 104. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies enabled elucidation of its structural features.

Original languageEnglish
Pages (from-to)1966-1969
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume38
Issue number7
DOIs
Publication statusPublished - 1990 Jan 1

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Keywords

  • Eucommia ulmoides
  • acidic polysaccharide
  • bark
  • eucomman A
  • immunological activity
  • methylation analysis
  • polysaccharide structure
  • reticuloendothelial system

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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