An adult patient with hypersensitivity to mosquito bites developing mantle cell lymphoma

Takehiko Mori, S. Okamoto, S. Kuramochi, Y. Ikeda

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Hypersensitivity to mosquito bites (HMB) has been known to occur exclusively in the first 2 decades of life and is frequently associated with Epstein-Barr virus (EBV) infection and lymphoproliferative diseases. We report here the first adult patient with HMB, a 61-year-old Japanese man who developed mantle cell lymphoma. EBV was detected in the lymph node by polymerase chain reaction and by in situ hybridization. Serum levels of interleukin (IL)-4, IL-6, and IL-10 were markedly increased, and the T-helper cell (Th)1/Th2 balance determined by intracellular cytokine levels was polarized to Th2. These findings suggest that the Th1/Th2 imbalance could partly be involved in the pathogenesis of HMB.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalInternational journal of hematology
Volume71
Issue number3
Publication statusPublished - 2000 Jan 1

Keywords

  • Epstein-barr virus
  • Hypersensitivity to mosquito bites
  • Mantle cell lymphoma
  • T-helper cell (Th)1/Th2 balance

ASJC Scopus subject areas

  • Hematology

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