An air-driven microdevice to tune the anisotropic curvature of cell adhesion plane to pursue the mechanobiology of curved surface

Tadahiro Yamashita, Ichiro Matsushita, Ryo Sudo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A new microdevice controlling the curvature of cell adhering plane is proposed. This microdevice is composed of a cell culture chamber with thin silicone membrane, a microslit and a vacuum chamber. Controlling the air pressure, the curvature of the cell adhering plane can be flexibly tuned in a spatiotemporal way. To prove the concept, vascular smooth muscle is cultured on the curved surface and their response to sudden curvature change is monitored. This microdevice would contribute to pursue fundamental question on how cells recognize the surrounding geometry, which is one of the core interests in the mechanobiology field.

Original languageEnglish
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages320-321
Number of pages2
ISBN (Electronic)9781733419000
Publication statusPublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: 2019 Oct 272019 Oct 31

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
CountrySwitzerland
CityBasel
Period19/10/2719/10/31

Keywords

  • Cellular orientation
  • Curvature
  • Mechanobiology
  • Smooth muscle cell

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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