An allylated firefly luciferin analogue with luciferase specific response in living cells

Yuma Ikeda; Tsuyoshi Saitoh; Kazuki Niwa; Takahiro Nakajima; Nobuo Kitada; Shojiro A. Maki; Moritoshi Sato; Daniel Citterio; Shigeru Nishiyama; Koji Suzuki

doi:10.1039/c7cc09720d

An allylated firefly luciferin analogue with luciferase specific response in living cells

Yuma Ikeda, Tsuyoshi Saitoh, Kazuki Niwa, Takahiro Nakajima, Nobuo Kitada, Shojiro A. Maki, Moritoshi Sato, Daniel Citterio, Shigeru Nishiyama, Koji Suzuki

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

An allylated firefly luciferin was successfully synthesized and its bioluminescence properties were evaluated. When applied to cellular imaging in combination with Eluc, which is one of the commercially available luciferases, this analogue displayed a luciferase-specific bioluminescence signal with prolonged emission (>100 min).

Original language	English
Pages (from-to)	1774-1777
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	14
DOIs	https://doi.org/10.1039/c7cc09720d
Publication status	Published - 2018

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c7cc09720d

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title = "An allylated firefly luciferin analogue with luciferase specific response in living cells",

abstract = "An allylated firefly luciferin was successfully synthesized and its bioluminescence properties were evaluated. When applied to cellular imaging in combination with Eluc, which is one of the commercially available luciferases, this analogue displayed a luciferase-specific bioluminescence signal with prolonged emission (>100 min).",

author = "Yuma Ikeda and Tsuyoshi Saitoh and Kazuki Niwa and Takahiro Nakajima and Nobuo Kitada and Maki, {Shojiro A.} and Moritoshi Sato and Daniel Citterio and Shigeru Nishiyama and Koji Suzuki",

note = "Funding Information: This study was supported by a Grant-in Aid for Scientific Research (S) (Grant No. 24225001) to K. S. from the Japan Society for the Promotion of Science (JSPS). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2018. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2018",

doi = "10.1039/c7cc09720d",

language = "English",

volume = "54",

pages = "1774--1777",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - An allylated firefly luciferin analogue with luciferase specific response in living cells

AU - Ikeda, Yuma

AU - Saitoh, Tsuyoshi

AU - Niwa, Kazuki

AU - Nakajima, Takahiro

AU - Kitada, Nobuo

AU - Maki, Shojiro A.

AU - Sato, Moritoshi

AU - Citterio, Daniel

AU - Nishiyama, Shigeru

AU - Suzuki, Koji

N1 - Funding Information: This study was supported by a Grant-in Aid for Scientific Research (S) (Grant No. 24225001) to K. S. from the Japan Society for the Promotion of Science (JSPS). Publisher Copyright: © The Royal Society of Chemistry 2018. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2018

Y1 - 2018

N2 - An allylated firefly luciferin was successfully synthesized and its bioluminescence properties were evaluated. When applied to cellular imaging in combination with Eluc, which is one of the commercially available luciferases, this analogue displayed a luciferase-specific bioluminescence signal with prolonged emission (>100 min).

AB - An allylated firefly luciferin was successfully synthesized and its bioluminescence properties were evaluated. When applied to cellular imaging in combination with Eluc, which is one of the commercially available luciferases, this analogue displayed a luciferase-specific bioluminescence signal with prolonged emission (>100 min).

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AN - SCOPUS:85042132490

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SP - 1774

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JO - Chemical Communications

JF - Chemical Communications

IS - 14

ER -

An allylated firefly luciferin analogue with luciferase specific response in living cells

Abstract

ASJC Scopus subject areas

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