An anthraquinone - Enzyme - peptide hybrid as a photo-switchable enzyme

Shota Sotokawa, Takashi Kitamura, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A purpose-designed anthraquinone-horseradish peroxidase (HRP)-cell penetrating peptide hybrid 1 showed high and effective cell permeability. Furthermore, 1 exhibited enzymatic activity without photo-irradiation, whereas significant self-degradation and loss of enzymatic activity occurred upon photo-irradiation in living cells.

Original languageEnglish
Pages (from-to)10614-10617
Number of pages4
JournalChemical Communications
Volume54
Issue number75
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Anthraquinones
Peptides
Enzymes
Irradiation
Cell-Penetrating Peptides
Horseradish Peroxidase
Cells
Degradation

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

An anthraquinone - Enzyme - peptide hybrid as a photo-switchable enzyme. / Sotokawa, Shota; Kitamura, Takashi; Takahashi, Daisuke; Toshima, Kazunobu.

In: Chemical Communications, Vol. 54, No. 75, 01.01.2018, p. 10614-10617.

Research output: Contribution to journalArticle

Sotokawa, Shota ; Kitamura, Takashi ; Takahashi, Daisuke ; Toshima, Kazunobu. / An anthraquinone - Enzyme - peptide hybrid as a photo-switchable enzyme. In: Chemical Communications. 2018 ; Vol. 54, No. 75. pp. 10614-10617.
@article{c10659643941473994214c9365a9b3a9,
title = "An anthraquinone - Enzyme - peptide hybrid as a photo-switchable enzyme",
abstract = "A purpose-designed anthraquinone-horseradish peroxidase (HRP)-cell penetrating peptide hybrid 1 showed high and effective cell permeability. Furthermore, 1 exhibited enzymatic activity without photo-irradiation, whereas significant self-degradation and loss of enzymatic activity occurred upon photo-irradiation in living cells.",
author = "Shota Sotokawa and Takashi Kitamura and Daisuke Takahashi and Kazunobu Toshima",
year = "2018",
month = "1",
day = "1",
doi = "10.1039/c8cc06130k",
language = "English",
volume = "54",
pages = "10614--10617",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "75",

}

TY - JOUR

T1 - An anthraquinone - Enzyme - peptide hybrid as a photo-switchable enzyme

AU - Sotokawa, Shota

AU - Kitamura, Takashi

AU - Takahashi, Daisuke

AU - Toshima, Kazunobu

PY - 2018/1/1

Y1 - 2018/1/1

N2 - A purpose-designed anthraquinone-horseradish peroxidase (HRP)-cell penetrating peptide hybrid 1 showed high and effective cell permeability. Furthermore, 1 exhibited enzymatic activity without photo-irradiation, whereas significant self-degradation and loss of enzymatic activity occurred upon photo-irradiation in living cells.

AB - A purpose-designed anthraquinone-horseradish peroxidase (HRP)-cell penetrating peptide hybrid 1 showed high and effective cell permeability. Furthermore, 1 exhibited enzymatic activity without photo-irradiation, whereas significant self-degradation and loss of enzymatic activity occurred upon photo-irradiation in living cells.

UR - http://www.scopus.com/inward/record.url?scp=85053554686&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053554686&partnerID=8YFLogxK

U2 - 10.1039/c8cc06130k

DO - 10.1039/c8cc06130k

M3 - Article

VL - 54

SP - 10614

EP - 10617

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 75

ER -