An autopsy case of unresectable colon cancer who developed lung injury by cetuximab

Junko Uemoto, Yasuo Hamamoto, Kei Onodera, Tomohiro Nishi, Etsuko Warita, Yasuhiro Yamanaka, Nobuo Hoshi, Kaoru Hirabayashi, Sayuri Hoshi, Seiji Igarashi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We report the case of a woman in her 60s with unresectable advanced colon cancer. After the first course of cetuximab as second-line therapy, she had developed drug-induced lung injury. Steroid pulse therapy had been ineffective, and she died of respiratory failure on day 9. The pathological examination of autopsy lung specimens revealed diffuse alveolar damage (DAD). Details of the cetuximab-induced lung injury are unclear. However, in 3 previous reports of lung injury by cetuximab, the postmortem findings were similar to this case. We concluded that DAD seems to be one of the pathological features of lung injury caused by cetuximab.

Original languageEnglish
Pages (from-to)245-247
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Volume40
Issue number2
Publication statusPublished - 2013 Jan 1

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Lung Injury
Colonic Neoplasms
Autopsy
Respiratory Insufficiency
Steroids
Lung
Cetuximab
Therapeutics
Pharmaceutical Preparations

Keywords

  • Cetuximab
  • Colorectal cancer
  • Diffuse alveolar damage

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

Cite this

Uemoto, J., Hamamoto, Y., Onodera, K., Nishi, T., Warita, E., Yamanaka, Y., ... Igarashi, S. (2013). An autopsy case of unresectable colon cancer who developed lung injury by cetuximab. Japanese Journal of Cancer and Chemotherapy, 40(2), 245-247.

An autopsy case of unresectable colon cancer who developed lung injury by cetuximab. / Uemoto, Junko; Hamamoto, Yasuo; Onodera, Kei; Nishi, Tomohiro; Warita, Etsuko; Yamanaka, Yasuhiro; Hoshi, Nobuo; Hirabayashi, Kaoru; Hoshi, Sayuri; Igarashi, Seiji.

In: Japanese Journal of Cancer and Chemotherapy, Vol. 40, No. 2, 01.01.2013, p. 245-247.

Research output: Contribution to journalArticle

Uemoto, J, Hamamoto, Y, Onodera, K, Nishi, T, Warita, E, Yamanaka, Y, Hoshi, N, Hirabayashi, K, Hoshi, S & Igarashi, S 2013, 'An autopsy case of unresectable colon cancer who developed lung injury by cetuximab', Japanese Journal of Cancer and Chemotherapy, vol. 40, no. 2, pp. 245-247.
Uemoto, Junko ; Hamamoto, Yasuo ; Onodera, Kei ; Nishi, Tomohiro ; Warita, Etsuko ; Yamanaka, Yasuhiro ; Hoshi, Nobuo ; Hirabayashi, Kaoru ; Hoshi, Sayuri ; Igarashi, Seiji. / An autopsy case of unresectable colon cancer who developed lung injury by cetuximab. In: Japanese Journal of Cancer and Chemotherapy. 2013 ; Vol. 40, No. 2. pp. 245-247.
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