An Evaluation Of Antimicrobial Removal Device To Isolate Bacteria From Bacteremic Patients With Hematological Disorders

Hajime Nakazawa, Shinichiro Okamoto, Tadashi Murase, Yohko Yoshh, Isao Aoki, Keisuke Toyama, Yasuhiko Ando, Hkoshi Uchida

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Antibiotics contained in blood specimens often inhibit bacterial growth in culture media. Recently, the antimicrobial removal device (ARD) containing resins to absorb antibiotics has been made available. To evaluate the effectiveness of the ARD, we investigated how much the antibiotics were removed by the ARD. The ARD method was compared to the conventional culturing method in isolating organisms from blood specimens of patients with hematological disorders receiving antimicrobial agents. The antibiotics, including cefotiam, cefsulodin, cefmenoxime, cefazolin and sulbenicillin, were proved to be almost completely removed by the ARD. Bacteria were detected only by use of the ARD in the blood cultures from 2 of 21 blood specimens (11 patients) entered in the study, while all of the blood cultures were negative by the conventional method. These isolated bacteria were S, aureus and P. aeruginosa, of which septicemias were cured by intensive antibiotic therapy for these bacteria. It is suggested that pretreatment with the ARD makes detection of bacteria easier in blood from the patients receivmg antibiotics. Literatures were reviewed concerning improvement and shortened time for isolation of organisms by usmg the ARD.

Original languageEnglish
Pages (from-to)1272-1278
Number of pages7
JournalJapanese Journal of Antibiotics
Issue number7
Publication statusPublished - 1984 Jan 1


ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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