An evaluation of novel biological activity in a crude extract from Hemerocallis fulva L. var. sempervirens M. Hotta

Kazuaki Taguchi, Keishi Yamasaki, Hiroki Maesaki, Masahiro Tokuno, Shoko Okazaki, Hiroshi Moriuchi, Keizo Takeshita, Masaki Otagiri, Hakaru Seo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Hemerocallis fulva L. var. sempervirens M. Hotta (kwanso) represents an exceptional resource for identifying and developing new phytomedicines for the treatment and prevention of disease. The aim of this study was to conduct a detailed investigation of the biological activities of kwanso. Our study resulted in four major findings. First, kwanso scavenges hydroxyl radicals generated by H2O2/UV light system in vitro in a dose-dependent manner. Second, hepatic glutathione levels were significantly increased when kwanso was orally administered to mice. Third, the oral administration of kwanso to mice showed a tendency to suppress hepatic injury induced by acetaminophen. Finally, kwanso slightly inhibited cytochrome P450 3A activity. These results provide useful evidence in support of the development of kwanso as a candidate raw material for the treatment and prevention of disease.

Original languageEnglish
Pages (from-to)2211-2213
Number of pages3
JournalNatural Product Research
Volume28
Issue number23
DOIs
Publication statusPublished - 2014 Dec 5
Externally publishedYes

Fingerprint

Hemerocallis
Hemerocallis fulva
disease prevention
Bioactivity
Complex Mixtures
bioactive properties
acetaminophen
Cytochrome P-450 CYP3A
liver
Liver
mice
extracts
hydroxyl radicals
Ultraviolet Rays
Acetaminophen
cytochrome P-450
Ultraviolet radiation
Hydroxyl Radical
oral administration
Glutathione

Keywords

  • biological activity
  • Hemerocallis fulva L. var. sempervirens M. Hotta
  • oriental medicine

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

Cite this

An evaluation of novel biological activity in a crude extract from Hemerocallis fulva L. var. sempervirens M. Hotta. / Taguchi, Kazuaki; Yamasaki, Keishi; Maesaki, Hiroki; Tokuno, Masahiro; Okazaki, Shoko; Moriuchi, Hiroshi; Takeshita, Keizo; Otagiri, Masaki; Seo, Hakaru.

In: Natural Product Research, Vol. 28, No. 23, 05.12.2014, p. 2211-2213.

Research output: Contribution to journalArticle

Taguchi, K, Yamasaki, K, Maesaki, H, Tokuno, M, Okazaki, S, Moriuchi, H, Takeshita, K, Otagiri, M & Seo, H 2014, 'An evaluation of novel biological activity in a crude extract from Hemerocallis fulva L. var. sempervirens M. Hotta', Natural Product Research, vol. 28, no. 23, pp. 2211-2213. https://doi.org/10.1080/14786419.2014.919285
Taguchi, Kazuaki ; Yamasaki, Keishi ; Maesaki, Hiroki ; Tokuno, Masahiro ; Okazaki, Shoko ; Moriuchi, Hiroshi ; Takeshita, Keizo ; Otagiri, Masaki ; Seo, Hakaru. / An evaluation of novel biological activity in a crude extract from Hemerocallis fulva L. var. sempervirens M. Hotta. In: Natural Product Research. 2014 ; Vol. 28, No. 23. pp. 2211-2213.
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