An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment

Takeshi Motohara, Kenta Masuda, Matteo Morotti, Yiyan Zheng, Salma El-Sahhar, Kay Yi Chong, Nina Wietek, Abdulkhaliq Alsaadi, Mohammad Karaminejadranjbar, Zhiyuan Hu, Mara Artibani, Laura Santana Gonzalez, Hidetaka Katabuchi, Hideyuki Saya, Ahmed Ashour Ahmed

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Metastasis is a complex multistep process that involves critical interactions between cancer cells and a variety of stromal components in the tumor microenvironment, which profoundly influence the different aspects of the metastatic cascade and organ tropism of disseminating cancer cells. Ovarian cancer is the most lethal gynecological malignancy and is characterized by peritoneal disseminated metastasis. Evidence has demonstrated that ovarian cancer possesses specific metastatic tropism for the adipose-rich omentum, which has a pivotal role in the creation of the metastatic tumor microenvironment in the intraperitoneal cavity. Considering the distinct biology of ovarian cancer metastasis, the elucidation of the cellular and molecular mechanisms underlying the reciprocal interplay between ovarian cancer cells and surrounding stromal cell types in the adipose-rich metastatic microenvironment will provide further insights into the development of novel therapeutic approaches for patients with advanced ovarian cancer. Herein, we review the biological mechanisms that regulate the highly orchestrated crosstalk between ovarian cancer cells and various cancer-associated stromal cells in the metastatic tumor microenvironment with regard to the omentum by illustrating how different stromal cells concertedly contribute to the development of ovarian cancer metastasis and metastatic tropism for the omentum.

Original languageEnglish
Pages (from-to)2885-2898
Number of pages14
JournalOncogene
Volume38
Issue number16
DOIs
Publication statusPublished - 2019 Apr 18

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Motohara, T., Masuda, K., Morotti, M., Zheng, Y., El-Sahhar, S., Chong, K. Y., Wietek, N., Alsaadi, A., Karaminejadranjbar, M., Hu, Z., Artibani, M., Gonzalez, L. S., Katabuchi, H., Saya, H., & Ahmed, A. A. (2019). An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment. Oncogene, 38(16), 2885-2898. https://doi.org/10.1038/s41388-018-0637-x