An HIV autopsy - Characterization of zidovudine-resistant subtype E HIV- 1 from autopsy tissue suggests the route of infection and an alternative protocol of therapy

M. Negishi, A. Umezawa, M. Katayama, Takeshi Kanda, T. Oguma, H. Maruyama, Mitsuru Murata, Y. Ohata, Y. Hiraishi, T. Sugita, Shingo Kato, J. I. Hata

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This CPC concerns a 47-year-old male patient with acquired immunodeficiency syndrome (AIDS). The patient became symptomatic when he developed Pneumocystis carinii pneumonia, but recovered sufficiently to be treated as an outpatient. Two years after falling ill, he developed septic shock and died within a short time. During this period, he failed to respond to HIV drugs, and there was no improvement in his immunodeficient status. The HIV retrieved from the patient's organs at autopsy was found to be type E and to have acquired resistance to Zidovudine. It was also possible to determine the route of infection. HIV treatment guidelines are continuously being revised on the basis of HIV research and the development of new treatment plans, and at the present time, when no definitive method of treatment has yet been established, it is essential for the clinician to keep abreast of the latest information. Since HIV patients are compromised hosts, it is important to diagnose and treat other infectious complications, not only complications unique to AIDS, and we have briefly described the latest HIV therapy.

Original languageEnglish
Pages (from-to)44-52
Number of pages9
JournalKeio Journal of Medicine
Volume48
Issue number1
Publication statusPublished - 1999

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Zidovudine
Complementary Therapies
HIV-1
Autopsy
HIV
Infection
Acquired Immunodeficiency Syndrome
Accidental Falls
Pneumocystis Pneumonia
Therapeutics
Septic Shock
Outpatients
Guidelines
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

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An HIV autopsy - Characterization of zidovudine-resistant subtype E HIV- 1 from autopsy tissue suggests the route of infection and an alternative protocol of therapy. / Negishi, M.; Umezawa, A.; Katayama, M.; Kanda, Takeshi; Oguma, T.; Maruyama, H.; Murata, Mitsuru; Ohata, Y.; Hiraishi, Y.; Sugita, T.; Kato, Shingo; Hata, J. I.

In: Keio Journal of Medicine, Vol. 48, No. 1, 1999, p. 44-52.

Research output: Contribution to journalArticle

Negishi, M, Umezawa, A, Katayama, M, Kanda, T, Oguma, T, Maruyama, H, Murata, M, Ohata, Y, Hiraishi, Y, Sugita, T, Kato, S & Hata, JI 1999, 'An HIV autopsy - Characterization of zidovudine-resistant subtype E HIV- 1 from autopsy tissue suggests the route of infection and an alternative protocol of therapy', Keio Journal of Medicine, vol. 48, no. 1, pp. 44-52.
Negishi, M. ; Umezawa, A. ; Katayama, M. ; Kanda, Takeshi ; Oguma, T. ; Maruyama, H. ; Murata, Mitsuru ; Ohata, Y. ; Hiraishi, Y. ; Sugita, T. ; Kato, Shingo ; Hata, J. I. / An HIV autopsy - Characterization of zidovudine-resistant subtype E HIV- 1 from autopsy tissue suggests the route of infection and an alternative protocol of therapy. In: Keio Journal of Medicine. 1999 ; Vol. 48, No. 1. pp. 44-52.
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