An inhibitor of the adipogenic differentiation of 3T3-L1 cells, yoshinone A, and its analogs, isolated from the marine cyanobacterium Leptolyngbya sp.

Toshiyasu Inuzuka, Keita Yamamoto, Arihiro Iwasaki, Osamu Ohno, Kiyotake Suenaga, Yoshinori Kawazoe, Daisuke Uemura

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Three novel compounds, yoshinones A, B1, and B2, were isolated from the marine cyanobacterium Leptolyngbya sp., and their structures were elucidated by NMR spectral analysis. Yoshinone A, but not yoshinone B1 or B2, inhibited the differentiation of 3T3-L1 cells into adipocytes. In addition, yoshinone A did not exhibit cytotoxicity, suggesting that yoshinone A may be useful in studies on the treatment of obesity.

Original languageEnglish
Pages (from-to)6711-6714
Number of pages4
JournalTetrahedron Letters
Volume55
Issue number49
DOIs
Publication statusPublished - 2014 Dec 3

Keywords

  • 3T3-L1 cells
  • Adipogenesis
  • Obesity
  • Yoshinone
  • γ-Pyrone

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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