An inhibitor of the adipogenic differentiation of 3T3-L1 cells, yoshinone A, and its analogs, isolated from the marine cyanobacterium Leptolyngbya sp.

Toshiyasu Inuzuka, Keita Yamamoto, Arihiro Iwasaki, Osamu Ohno, Kiyotake Suenaga, Yoshinori Kawazoe, Daisuke Uemura

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Three novel compounds, yoshinones A, B1, and B2, were isolated from the marine cyanobacterium Leptolyngbya sp., and their structures were elucidated by NMR spectral analysis. Yoshinone A, but not yoshinone B1 or B2, inhibited the differentiation of 3T3-L1 cells into adipocytes. In addition, yoshinone A did not exhibit cytotoxicity, suggesting that yoshinone A may be useful in studies on the treatment of obesity.

Original languageEnglish
Pages (from-to)6711-6714
Number of pages4
JournalTetrahedron Letters
Volume55
Issue number49
DOIs
Publication statusPublished - 2014 Dec 3

Fingerprint

3T3-L1 Cells
Cyanobacteria
Cytotoxicity
Adipocytes
Spectrum analysis
Obesity
Nuclear magnetic resonance

Keywords

  • 3T3-L1 cells
  • Adipogenesis
  • Obesity
  • Yoshinone
  • γ-Pyrone

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

An inhibitor of the adipogenic differentiation of 3T3-L1 cells, yoshinone A, and its analogs, isolated from the marine cyanobacterium Leptolyngbya sp. / Inuzuka, Toshiyasu; Yamamoto, Keita; Iwasaki, Arihiro; Ohno, Osamu; Suenaga, Kiyotake; Kawazoe, Yoshinori; Uemura, Daisuke.

In: Tetrahedron Letters, Vol. 55, No. 49, 03.12.2014, p. 6711-6714.

Research output: Contribution to journalArticle

@article{0f0a6119ab09419896c2dd814bfe1f34,
title = "An inhibitor of the adipogenic differentiation of 3T3-L1 cells, yoshinone A, and its analogs, isolated from the marine cyanobacterium Leptolyngbya sp.",
abstract = "Three novel compounds, yoshinones A, B1, and B2, were isolated from the marine cyanobacterium Leptolyngbya sp., and their structures were elucidated by NMR spectral analysis. Yoshinone A, but not yoshinone B1 or B2, inhibited the differentiation of 3T3-L1 cells into adipocytes. In addition, yoshinone A did not exhibit cytotoxicity, suggesting that yoshinone A may be useful in studies on the treatment of obesity.",
keywords = "3T3-L1 cells, Adipogenesis, Obesity, Yoshinone, γ-Pyrone",
author = "Toshiyasu Inuzuka and Keita Yamamoto and Arihiro Iwasaki and Osamu Ohno and Kiyotake Suenaga and Yoshinori Kawazoe and Daisuke Uemura",
year = "2014",
month = "12",
day = "3",
doi = "10.1016/j.tetlet.2014.10.032",
language = "English",
volume = "55",
pages = "6711--6714",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "49",

}

TY - JOUR

T1 - An inhibitor of the adipogenic differentiation of 3T3-L1 cells, yoshinone A, and its analogs, isolated from the marine cyanobacterium Leptolyngbya sp.

AU - Inuzuka, Toshiyasu

AU - Yamamoto, Keita

AU - Iwasaki, Arihiro

AU - Ohno, Osamu

AU - Suenaga, Kiyotake

AU - Kawazoe, Yoshinori

AU - Uemura, Daisuke

PY - 2014/12/3

Y1 - 2014/12/3

N2 - Three novel compounds, yoshinones A, B1, and B2, were isolated from the marine cyanobacterium Leptolyngbya sp., and their structures were elucidated by NMR spectral analysis. Yoshinone A, but not yoshinone B1 or B2, inhibited the differentiation of 3T3-L1 cells into adipocytes. In addition, yoshinone A did not exhibit cytotoxicity, suggesting that yoshinone A may be useful in studies on the treatment of obesity.

AB - Three novel compounds, yoshinones A, B1, and B2, were isolated from the marine cyanobacterium Leptolyngbya sp., and their structures were elucidated by NMR spectral analysis. Yoshinone A, but not yoshinone B1 or B2, inhibited the differentiation of 3T3-L1 cells into adipocytes. In addition, yoshinone A did not exhibit cytotoxicity, suggesting that yoshinone A may be useful in studies on the treatment of obesity.

KW - 3T3-L1 cells

KW - Adipogenesis

KW - Obesity

KW - Yoshinone

KW - γ-Pyrone

UR - http://www.scopus.com/inward/record.url?scp=84910028850&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84910028850&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2014.10.032

DO - 10.1016/j.tetlet.2014.10.032

M3 - Article

AN - SCOPUS:84910028850

VL - 55

SP - 6711

EP - 6714

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 49

ER -