An integrated map with cosmid/PAC contigs of a 4-Mb Down syndrome critical region

Kazutoyo Osoegawa, Rie Susukida, Saishi Okano, Jun Kudoh, Shinsei Minoshima, Nobuyoshi Shimizu, Pieter J. De Jong, Juergen Groet, Jane Ives, Hans Lehrach, Dean Nizetic, Eiichi Soeda

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The major phenotypic features of Down syndrome have been correlated with partial trisomies of chromosome 21, allowing us to define the candidate gene region to a 4-Mb segment on the 21q22.2 band. We present here a high- resolution physical map with megabase-sized cosmid/PAC contigs. This ordered clone library has provided unique material for the integration of a variety of mappable objects, including exons, cDNAs, restriction sites, etc. Furthermore, our results have exemplified a strategy for the completion of the chromosome 21 map to sequencing.

Original languageEnglish
Pages (from-to)375-387
Number of pages13
JournalGenomics
Volume32
Issue number3
DOIs
Publication statusPublished - 1996 Mar 15

ASJC Scopus subject areas

  • Genetics

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    Osoegawa, K., Susukida, R., Okano, S., Kudoh, J., Minoshima, S., Shimizu, N., De Jong, P. J., Groet, J., Ives, J., Lehrach, H., Nizetic, D., & Soeda, E. (1996). An integrated map with cosmid/PAC contigs of a 4-Mb Down syndrome critical region. Genomics, 32(3), 375-387. https://doi.org/10.1006/geno.1996.0132